个人简介

1961年11月生于湖北武汉。研究方向：兽医药理学与药剂学。现任华中农业大学动物医学院教授，博士生导师，兼任中国兽药典委员会委员，中国兽医药理学与毒理学学会理事，湖北省畜牧兽医学会理事，湖北实验动物学会理事，湖北省动物保健品协会名誉会长。从事兽医药理学、兽医临床药理学、毒理学、药物动力学、生物统计学、药剂学教学、科研、生产和技术咨询等工作,为全国部分兽药生产厂家研究兽药制剂配方与生产工艺120余种。主持、参加国家自然科学基金、国家攻关及省部级重点研究项目6项，获国家及省部级奖励5项。在《Scientific Reports》、《Oncotarget》、《Frontiers in pharmacology》、《Frontiers in microbology》等学术刊物和会议上发表研究论文70余篇，主编及参编多部专著：兽医药物动力学主编，兽医药理学与治疗学主译，饲料药物学副主编，国家规划教材2部副主编。

教育经历

1978.09 - 1982.07，华中农业大学，兽医专业毕业，农学学士
1982.09 - 1985.07，华中农业大学，兽医药理学专业毕业，农学硕士
2001.09-2004.07，华中农业大学，动物遗传育种与繁殖专业毕业，农学博士

工作经历

1985.07-2003.12，华中农业大学副教授、硕生导师
2003.12- 至今，华中农业大学教授，博士生导师

研究领域

兽医药理学与毒理学、药物动力学、药剂学等

科研成果

A著作类
1.《药物动力学》主编和参编著作8部。
2. 《兽医药理学与治疗学》主译和参编著作8部。
B论文类
1. The Pharmacokinetic-Pharmacodynamic Modeling and Cut-off values of Tildipirosin against Haemophilus parasuis. ONCOTARGET 2017.11
2. PK-PD Analysis of marbofloxacin against Streptococcus suis in pigs FRONTIERS IN PHAEMACOLOGY 2017.11
3. Combination Susceptibility Testing of Common Antimicrobials in Vitro and the Effects of Sub-MIC of Antimicrobials on Staphylococcus aureus Biofilm Formation FRONTIERS IN MICROBIOLOGY 2017.10
4. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modelling against Escherichia coli in Pigs FRONTIERS IN PHAEMACOLOGY 2017.08
5. Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis SCIENTIFIC REPORTS 2017.08
6. Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs FRONTIERS IN PHAEMACOLOGY 2017.05
7. Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs FRONTIERS IN VETERINARY SCIENCE 2017.05
8. Preparation and evaluation of cefquinome-loaded gelatin microspheres and the pharmacokinetics in pigs JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 2017.01
9. Deletion of HAPS_2096 Increases Sensitivity to Cecropin B in Haemophilus parasuis JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY 2015.09
10. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721 PLOS ONE 2015.06
11. Expression and biochemical characterization of recombinant human epididymis protein 4 PROTEIN EXPRESSION AND PURIFICATION 2014.10
12. Highly efficient production of peptides: N-glycosidase F for N-glycomics analysis PROTEIN EXPRESSION AND PURIFICATION 2014.04
13. Reaction temperature alters chorzoxazone metabolism in carp (Cyprinus carpio) hepatic microsomes FISH PHYSIOLOGY AND BIOCHEMISTRY 2012.01
14. Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2012.01
15. Molecular Characteristics of the Porcine TIMD4 Gene and Its Association Analysis BIOCHEMICAL GENETICS?? 2012.01
16. Characterization of the porcine p65 subunit of NF-kappa B and its association with virus antibody levels MOLECULAR IMMUNOLOGY 2011.01
17. Molecular Characterization of Tob1 in Muscle Development in Pigs INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2011.01

科研项目

1. 肠泰的临床药效学试验 2013.01
2. 茯苓发酵合作协议 2012.01
3. 茯苓散的药效学和临床疗效研究协议 2012.01
4. 10%恩诺沙星肠溶微丸临床实验室委托协议 2012.01
5. 麻保沙星原料药及其片剂的临床试验研究协议 2012.01
6. 生物等效性试验项目委托研究协议 2011.01

主要奖励

1.以第一完成人获得发明专利2项，参与相关研究获发明专利26项。
2. 指导参与三、四类新兽药申报4项。
3.2007、2008年两次获湖北省重大科学技术成果奖
4.2005年指导硕士论文获湖北省第十届自然科学优秀学术论文二等奖