• 司有辉

• 系所

  预防兽医学系

• 职称

  教授

• 办公房间

  协同创新中心503

• email

  youhui@mail.hzau.edu.cn

• 讲授课程

  《兽医免疫学》等

个人简介

司有辉，男，华中农业大学教授、博士生导师。主要从事树突状细胞(DCs)抗原高效递呈与保护性免疫应答机制的研究，重点聚焦动物DCs与病原相互作用及其诱导获得性免疫应答机制、猪重大疫病与人兽共患病免疫逃逸机制等前沿基础科学问题，同时利用材料化学、免疫学和病原微生物学等多学科交叉融合和技术创新，研发防控技术与产品。近年来以第一作者或共同一作发表Science Advances(IF=14.094)论文2篇，Hepatology(IF=13.663)1篇，J Control Release(IF=8.626)1篇以及其他一作或共同一作SCI论文共11篇，获国家授权专利2项，主持完成国家基金1项。

教育经历

2000.09 - 2004.06， 华中农业大学，动物医学专业，农学学士
2004.09 - 2009.06， 华中农业大学，预防兽医学专业，农学博士

工作经历

2009.08 - 2013.09， 中国医学科学院/北京协和医学院病原生物学研究所，助理研究员
2013.10 - 2015.06， 中国医学科学院/北京协和医学院病原生物学研究所，副研究员，硕士生导师
2015.07 - 2017.05， 美国芝加哥大学医学院，博士后
2017.06 - 2021.05， 美国芝加哥大学医学院，Research Scientist
2021.06 - 至今，华中农业大学教授、博士生导师

研究领域

DCs与病原相互作用及其诱导获得性免疫应答机制、新型纳米材料疫苗与佐剂的研发。

科研成果

1.Si Y, Tian Q, Zhao F, Kelly S, Shores L, Camacho D, Sperling A, Collier J, Chong AS. Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and Th17 responses. Science Advances. 07 Aug 2020: Vol. 6, no. 32, eaba0995. DOI: 10.1126/sciadv.aba0995.
2.Si Y*, Zhao F*, Beesetty P, Weiskopf D, Li Z, Tian Q, Alegre ML, Sette A, Chong AS, Montgomery CP. Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination. Science Advances. 01 Apr 2020: Vol. 6, no. 14, eaaw7713. DOI: 10.1126/sciadv.aaw7713. (*Co-first author)
3.Si Y*, Wen Y*, Kelly SH, Chong AS, Collier JH. Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses. J Control Release. 2018 Apr 16. pii: S0168-3659(18)30216-5. (*Co-first author)
4.Si Y, Liu S, Liu X, Jacobs J, Cheng M, Niu Y, Jin Q, Wang T, Yang W. A Human Claudin-1 Derived Peptide Inhibits Hepatitis C Virus Entry. Hepatology. 2012, 56(2): 507-515.
5.Si Y*, Wen Y*, Chen J, Pompano RR, Han H, Collier J, Chong AS. MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination. Medchemcomm. 2018;9(1):138-148. (*Co-first author)
6.Niu Y*, Si Y*, Li Y, Chi X, Li X, Liu X, Li D, Cheng M, Fan J, Jin Q, Si S, Yang W. A novelsmall-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription. J Antimicrob Chemother, 2015 Jul; 70(7):2013-23. (*Co-first author)
7.Si Y*, Li J*, Niu Y*, Liu X, Ren L, Guo L, Cheng M, Zhou H, Wang J, Jin Q, Yang W. Entry Properties and Entry Inhibitors of a Human H7N9 Influenza Virus. PLoS One. 2014 Sep 15; 9(9):e107235. (*Co-first author)
8.Cheng M*, Si Y*, Niu Y, Liu X, Li X, Zhao J, Jin Q, Yang W. High-throughput profiling of IFNα and IL-28B regulated microRNAs and identification of let-7s with anti-HCV activity by targeting IGF2BP1. J Virol. 2013 Sep; 87(17):9707-18. (*Co-first author)
9.Zhao J*,Si Y*§, Cheng M*, Yang Y, Niu Y, Li X, Liu X, Yang W§. Albumin fusion of interleukin-28B: production and characterization of its biological activities and protein stability. PLoS One. 2013 May 31; 8(5):e64301. (*Co-first author, §Co-corresponding author)
10.Si Y*, Liu X*, Cheng M, Wang M, Gong Q, Yang Y, Wang T, Yang W. Growth Differentiation Factor 15 Is Induced by Hepatitis C Virus Infection and Regulates Hepatocellular Carcinoma-Related Genes. PLoS One.2011, 6(5): e19967. (*Co-first author)
11.Si Y, Yuan F, Chang H, Liu X, Li H, Cai K, Xu Z, Huang Q, Bei W, Chen H. Contribution of glutamine synthetase to the virulence of Streptococcus suisserotype 2. Vet Microbiol. 2009 Oct 20; 139(1-2):80-8.
12.Liu X, Chi X, Gong Q, Gao L, Niu Y, Chi X, Cheng M, Si Y, Wang M, Zhong J, Niu J, Yang W.Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma. PLoS One. 2015 May 21;10(5):e0127518.
13.Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W. Screening and rational design of HCV entry inhibitory peptides derived from GBV-A NS5A. J Virol. 2013, 87(3): 1649-1657.
14.Cheng M, Si Y, Yang Y, Liu X, Gong Q, Zhao J, Niu Y, Li X, Jin Q, Yang W. Recombinant human interleukin-28B: anti-HCV potency, receptor usage and restricted cell-type responsiveness. J Antimicrob Chemother, 2012, 67(5): 1080-1087.
15.Gong Q, Cheng M, Chen H, Liu X, Si Y, Yang Y, Yuan Y, Jin C, Yang W, He F, Wang J. Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells. FEBS Lett. 2011 Sep 2; 585(17):2647-52.
16.Huang Q, Yao Q, Fan H, Xiao S, Si Y, Chen H. Development of a vaccine vector based on a subgenomic replicon of porcine reproductive and respiratory syndrome virus. J Virol Methods. 2009 Sep; 160(1-2):22-8.
17.Xu Z, Chao Y, Si Y, Wang J, Jin M, Guo A, Qian P, Zhou R, Chen H. The GTP binding sites interacted with RNA-dependent RNA polymerase of classical swine fever virus in de novo initiation. In Silico Biol. 2008; 8(1):21-32.
Yao Q, Qian P, Cao Y, He Y, Si Y, Xu Z, Chen H. Synergistic inhibition of pseudorabies virus replication by porcine alpha/beta interferon and gamma interferon in vitro. Eur Cytokine Netw. 2007 Jun; 18(2):71-7.

科研项目

华中农业大学高层人才启动基金

主要奖励