个人简介

霍立军，男，黑龙江人。华中农业大学教授，博士生导师，动物繁殖与特经系副系主任。教育部新世纪优秀人才（2008），霍英东基金获得者。东北农业大学理学学士和基础兽医学硕士，中科院动物所理学博士。中国动物学会细胞及分子显微技术学分会理事，中国动物学会生殖生物学分会理事。研究领域为哺乳动物卵巢生殖生理，集中在卵母细胞减数分裂成熟及成熟卵子质量调控等。在SCI期刊发表第一或通讯作者科研论文30余篇，参与编译专著《小鼠胚胎操作实验手册》。获得2004年教育部提名国家科技奖二等奖及2004年黑龙江省科学技术三等奖。先后承担农业部转基因动物项目、教育部新世纪优秀人才支持计划项目、霍英东基金基础性研究项目、教育部博士点基金、国家自然科学基金面上项目等。

教育经历

1995.09－1999.09，东北农业大学，生物技术系，理学学士
1999.09－2002.09，东北农业大学，生命科学学院，基础兽医学硕士
2002.09－2005.09，中国科学院动物研究所，计划生育生殖生物学国家重点实验室，理学博士
2005.09－2008.09，Stowers Institute for Medical Research，博士后，导师：Scott Hawley

工作经历

2008.08-至今，华中农业大学教授、博士生导师，动物繁殖与特经系副系主任。

研究领域

哺乳动物卵子成熟调控机制，成熟卵子质量控制和影响因素。

科研成果

A著作类
1.《小鼠胚胎操作实验手册》，孙青原，陈大元主译。霍立军编译“植入前胚胎的收集和体外培养”一章。化学工业出版社
B论文类（#第一作者，*通讯作者）
Ding ZM#, Jiao XF, Wu D, Zhang JY, Chen F, Wang YS, Huang CJ, Zhang SX, Li X, Huo LJ*. Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage. Chem Biol Interact. 2017 Nov 1. pii: S0009-2797(17)31017-7.
Brohi RD#, Wang L, Talpur HS, Wu D, Khan FA, Bhattarai D, Rehman ZU, Farmanullah F, Huo LJ*. Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review. Front Pharmacol. 2017 Sep 5;8:606. doi: 10.3389/fphar.2017.00606. eCollection 2017. Review.
Brohi RD#, Wang L, Hassine NB, Cao J, Talpur HS, Wu D, Huang CJ, Rehman ZU, Bhattarai D, Huo LJ*. Expression, Localization of SUMO-1, and Analyses of Potential SUMOylated Proteins in Bubalus bubalis Spermatozoa. Front Physiol. 2017 Jun 13;8:354. doi: 10.3389/fphys.2017.00354.
Ding ZM#, Huang CJ, Jiao XF, Wu D, Huo LJ*. The role of TACC3 in mitotic spindle organization. Cytoskeleton (Hoboken). 2017 Jul 26. doi: 10.1002/cm.21388.
Brohi RD#, Huo LJ*. Posttranslational Modifications in Spermatozoa and Effects on Male Fertility and Sperm Viability. OMICS: A Journal of Integrative Biology. 2017 May;21(5):245-256.
Wu D#, Huang CJ, Khan FA, Jiao XF, Liu XM, Pandupuspitasari NS, Brohi RD, Huo LJ*. SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells. Oncotarget. 2017 Apr 7. doi: 10.18632/oncotarget.16915.
Huang CJ#, Wu D, Jiao XF, Khan FA, Xiong CL, Liu XM, Yang J, Yin TL, Huo LJ*. Maternal SENP7 programs meiosis architecture and embryo survival in mouse. Biochim Biophys Acta. 2017 Mar 16;1864(7):1195-1206. doi: 10.1016/j.bbamcr.2017.03.005.
Jiao XF*, Huang CJ, Wu D, Zhang JY, Long YT, Chen F, Li X, Huo LJ#. Abce1 orchestrates M-phase entry and cytoskeleton architecture in mouse oocyte. Oncotarget. 2017 Mar 24. doi: 10.18632/oncotarget.16546.
Wang L#, Zhen Y, Liu X, Cao J, Wang Y, Huo L*. Inhibition of calcineurin by FK506 stimulates germinal vesicle breakdown of mouse oocytes in hypoxanthine-supplemented medium. PeerJ 2017 Feb 23 5:e3032 doi: 10.7717/peerj.3032.
Huang CJ#, Yuan YF, Wu D, Khan FA, Jiao XF, Huo LJ*. The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis. In Vitro Cell Dev Biol Anim. 2017 Mar;53(3):258-264.
Yang, Feifei#，Xiong, Jiajun，Liu, Xiaoming，Riaz, Hasan，Wang, Li，Cao, Jing，Khan, Faheem Ahmed，Huo, Lijun*，SUMOylation of PTX3 at Lysine 203 Regulates its Subcellular Localization in Mouse Ovarian Granulosa Cells. Pakistan Veterinary Journal. 2017.01.01，37(1)：25~30
Huang C#, Wu D, Khan FA, Jiao X, Guan K, Huo L*. The GTPase SPAG-1 orchestrates meiotic program by dictating meiotic resumption and cytoskeleton architecture in mouse oocytes. Mol Biol Cell. 2016 Jun 1;27(11):1776-85.
Huang CJ#, Wu D, Khan FA, Huo LJ*. The SUMO Protease SENP3 Orchestrates G2-M Transition and Spindle Assembly in Mouse Oocytes. Sci Rep. 2015 Oct 23;5:15600.
Huang CJ#, Wu D, Khan FA, Huo LJ*. DeSUMOylation: An Important Therapeutic Target and Protein Regulatory Event. DNA Cell Biol. 2015 Nov;34(11):652-60.
Khan HA#, Zhao Y, Wang L, Li Q, Du YA, Dan Y, Huo LJ*. Identification of miRNAs during mouse postnatal ovarian development and superovulation. J Ovarian Res. 2015 Jul 8;8(1):44.
Yuan YF#, Zhai R, Liu XM, Khan HA, Zhen YH, Huo LJ*. SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation. Mol Reprod Dev. 2014 Aug;81(8):712-24.
Zhen YH#, Wang L, Riaz H, Wu JB, Yuan YF, Han L, Wang YL, Zhao Y, Dan Y, Huo LJ*. Knockdown of CEBPβ by RNAi in porcine granulosa cells resulted in S phase cell cycle arrest and decreased progesterone and estradiol synthesis. J Steroid Biochem Mol Biol. 2014 Mar 4;143C:90-98.
Liu XM#, Yang FF, Yuan YF, Zhai R, Huo LJ*. SUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells. PLoS One. 2013 May 16;8(5):e63680.
Zhai R#, Yuan YF, Zhao Y, Liu XM, Zhen YH, Yang FF, Wang L, Huang CZ, Cao J, Huo LJ*. Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis. Mol Reprod Dev. 2013 Jun;80(6):474-87.
Huo L-J#, Fan H-Y, Liang C-G, Yu L-Z, Zhong Z-S, Chen D-Y, Sun Q-Y*. Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization. Biol Reprod 2004; 71:853-62.
Huo L-J#, Fan H-Y, Zhong Z-S, Chen D-Y, Schatten H, Sun Q-Y*. Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation. Mech Dev 2004; 121:1275-87.
Huo L-J#, Liang C-G, Yu L-Z, Zhong Z-S, Yang Z-M, Fan H-Y, Chen D-Y, Sun Q-Y*. Inducible nitric oxide synthase-derived nitric oxide regulates germinal vesicle breakdown and first polar body emission in the mouse oocyte. Reproduction 2005; 129:403-9.
Huo L-J#, Ma X-H, Yang Z-M*. Assessment of sperm viability, mitochondrial activity, capacitation and acrosome intactness in extended boar semen during long-term storage. Theriogenology 2002; 58:1349-60.
Huo LJ#, Yang ZM*. Effects of platelet activating factor on capacitation and acrosome reaction in mouse spermatozoa. Mol Reprod Dev 2000; 56:436-40.
Huo L-J#, Yu L-Z, Liang C-G, Fan H-Y, Chen D-Y, Sun Q-Y*. Cell-cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse. Zygote 2005; 13:45-53.
Huo L-J#, Yue K-Z, Yang Z-M*. Characterization of viability, mitochondrial activity, acrosomal integrity and capacitation status in boar sperm during in vitro storage at different ambient temperatures. Reprod Fertil Dev 2002; 14:509-14.
Huo L-J#, Zhong Z-S, Liang C-G, Wang Q, Yin S, Ai J-S, Yu L-Z, Chen D-Y, Schatten H, Sun Q-Y*. Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition. Front Biosci 2006; 11:2193-202.

科研项目

1. 国家自然科学基金面上项目，小鼠卵泡不同发育阶段差异表达microRNA的筛选鉴定和功能研究，2012.01
2. 国家自然科学基金面上项目， Sumo-1在小鼠卵巢颗粒细胞中的作用和机制研究，2011.01
3. 教育部博士点基金，猪卵丘细胞中MAPK的上下游信号途径及调控机制研究，2011.01
4. 霍英东基金基础性研究项目，钙调节神经磷酸酶在猪卵母细胞减数分裂成熟和受精中的作用和机制研究，2011.01
5. 教育部新世纪优秀人才， Sumo化在小鼠和猪卵母细胞减数分裂染色体分离过程中的作用和机制研究，2009.01

主要奖励

1. 2004年教育部提名国家科技奖二等奖，胚胎着床分子机理的研究。杨增明、倪华、岳占碰、肖丽娟、丁乃峥、霍立军、李世杰、马兴红、刁红录、徐立滨、王洪斌。
2. 2004年黑龙江省科学技术奖三等奖（自然科学类），猪精液的低温保存及精子的生理特性研究。杨增明、霍立军、徐立滨、岳奎中。