个人简介

史月军，男，河北高邑人。现为华中农业大学动物科学技术学院-动物医学院副研究员。2016年6月于华中农业大学预防兽医系获得农学博士学位。先后在华中农业大学生命科学技术学院（2016年7月至2019年6月）、动物科学技术学院-动物医学院（2019年7月至2021年5月）开展博士后研究，2021年6月进入华中农业大学工作。主要研究方向为人兽共患病病毒入侵机制研究与防控产品研发。目前已在《Nature Communications》、《Journal of Virology》、《Emerging Microbes & Infections》、《Journal of Biological Chemistry》等杂志上发表研究论文17篇，主持省部级以上基金三项。

教育经历

2013.07 - 2016.06，华中农业大学，预防兽医学，博士
2010.09 - 2013.6，华中农业大学，基础兽医学，硕士

工作经历

2021.06 - 至今，华中农业大学，动物科学技术学院-动物医学院，副研究员
2019.07 - 2021.5，华中农业大学，动物科学技术学院-动物医学院，博士后
2016.07 - 2019.06，华中农业大学，生命科学技术学院，博士后

研究领域

1.通过病毒学、结构生物学方法探究动物冠状病毒入侵、复制分子机制；2. 动物重要病原体防控产品研发

科研成果

1.Song X#, Shi Y#, Ding W#, Niu T, Sun L, Tan Y, Chen Y, Shi J, Xiong Q, Huang X, Xiao S, Zhu Y, Cheng C, Fu ZF, Liu ZJ*, Peng G*. 2021. Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes. Nature Communications 12:141.
2.Shi Y, Li Y, Lei Y, Ye G, Shen Z, Sun L, Luo R, Wang D, Fu ZF, Xiao S, Peng G*. 2016. A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of Porcine Reproductive and Respiratory Syndrome Virus nsp11. Journal of Virology 90:4579-4592.
3.Shi Y#, Shuai L#, Wen Z, Wang C, Yan Y, Jiao Z, Guo F, Fu ZF, Chen H, Bu Z*, Peng G*. 2021. The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Emerging Microbes & Infections 10:481-492.
4.Shi Y#, Tong X#, Ye G, Xiu R, Li L, Sun L, Shi J, Li M, Song Y, Fan C, Shi K, Fu ZF, Xiao S, Peng G*. 2020. Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus. Journal of Virology 94.
5.Shi Y#, Shi J#, Sun L#, Tan Y, Wang G, Guo F, Hu G, Fu Y, Fu ZF, Xiao S, Peng G*. 2021. Insight into vaccine development for Alpha-coronaviruses based on structural and immunological analyses of spike proteins. Journal of Virology 02284-20.
6.Zheng A#, Shi Y#, Shen Z, Wang G, Shi J, Xiong Q, Fang L, Xiao S, Fu ZF, Peng G*. 2018. Insight into the evolution of nidovirus endoribonuclease based on the finding that nsp15 from porcine Deltacoronavirus functions as a dimer. Journal of Biological Chemistry 293:12054-12067.
7.Shi Y, Lei Y, Ye G, Sun L, Fang L, Xiao S, Fu ZF, Yin P, Song Y*, Peng G*. 2018. Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus. Veterinary Microbiology 213:114-122.
8.Shi Y, Hu Z, Xiong Z, Zhou Y, Jin X, Gu C, Hu X, Cheng G, Song N, Zhang W*. 2013. Analysis of molecular variation of porcine reproductive and respiratory syndrome virus in Central China from 2006 to 2012. Archives of Virology 158:717-21.
9.Guo F, Shi Y, Yang M, Guo Y, Shen Z, Li M, Chen Y, Liang R, Yang Y, Chen H, Peng G*. 2021. The structural basis of African swine fever virus core shell protein p15 binding to DNA. The FASEB Journal 35:e21350.
10.Tan Y, Sun L, Wang G, Shi Y, Dong W, Fu Y, Fu Z, Chen H, Peng G*. 2021. The trypsin-enhanced infection of porcine epidemic diarrhea virus is determined by the S2 subunit of the spike glycoprotein. Journal of Virology 02453-20.
11.Zhu X, Liu S, Wang X, Luo Z, Shi Y, Wang D, Peng G, Chen H, Fang L*, Xiao S*. 2018. Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection. Emerging Microbes & Infections 7:65.
12.Li M, Ye G, Si Y, Shen Z, Liu Z, Shi Y, Xiao S, Fu ZF, Peng G*. 2021. Structure of the multiple functional domains from coronavirus nonstructural protein 3. Emerging Microbes & Infections 10:66-80.
13.Liang R, Wang G, Zhang D, Ye G, Li M, Shi Y, Shi J, Chen H, Peng G*. 2020. Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development. Journal of Biological Chemistry 296.
14.Ye G#, Wang X#, Tong X, Shi Y, Fu ZF, Peng G*. 2020. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376. Viruses 12.
15.Wang G, Liang R, Liu Z, Shen Z, Shi J, Shi Y, Deng F, Xiao S, Fu ZF, Peng G*. 2019. The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets. Viruses 11.
16.Li Y#, Dong W#, Shi Y, Deng F, Chen X, Wan C, Zhou M, Zhao L, Fu ZF*, Peng G*. 2016. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Virology 488:216-24.
Hu Z, Peng F, Xiong Z, Zhang W, Li T, Shi Y, Xie J, Jin X, Huang J, Xiao H, Bi D, Song N*, Li Z*. 2020. Genetic and Molecular Characterization of H9N2 Avian Influenza Viruses Isolated from Live Poultry Markets in Hubei Province, Central China, 2013-2017. Virologica Sinica doi:10.1007/s12250-020-00260-z.

科研项目

主持国家自然科学基金青年科学基金一项、中国博士后科学基金面上项目两项。

主要奖励

优秀博士后（2020）