个人简介

2014年12月于华中农业大学预防兽医学专业获得博士学位，2015年1月至2018年6月于华中农业大学生物学博士后流动站从事博士后研究，2017年4月至2018年4月年作为访问学者赴美国圣路易斯华盛顿大学医学院开展研究。主要专注于人兽共患病毒病免疫与致病机制的研究，以及宠物新型疫苗和诊断试剂的开发。先后主持自然科学基金青年基金、博士后特别资助与面上资助各一项、作为课题负责人和研究骨干分别参与国家重点研发计划项目两项。以第一作者和通讯作者在Science signaling、Journal of Immunology、Journal of virology等权威期刊发表SCI论文共19篇。

教育经历

2001.09-2005.07，华中农业大学，生物科学（国家生物学基地班），理学学士
2005.09-2008.07，华中农业大学，预防兽医学，农学硕士
2011.09-2014.12，华中农业大学，预防兽医学，农学博士

工作经历

2008.10-2009.11，New England Biolabs（上海研发中心），研发助理
2009.11-2011.08，华中农业大学动物医学院，科研助理
2015.01-2018.06，华中农业大学生物学博士后流动站，博士后
2017.04-2018.04，美国圣路易斯华盛顿大学医学院，访问学者
2018.06-2020.12，华中农业大学动物医学院预防兽医学系，副研究员，硕士生导师
2021.01-至今，华中农业大学动物医学院预防兽医学系，教授，博士生导师

研究领域

媒介传播人兽共患传染病致病与免疫机制、防控技术与产品研发。

科研成果

A著作类
B论文类
1、Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*.Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus. Science Signaling, 2016, 9(448): ra98.
2、Jing Ye, Zheng Chen, Yunchuan Li, Zikai Zhao, Wen He, Ali Zohaib, Yunfeng Song, Chenglin Deng, Bo Zhang, Huanchun Chen, Shengbo Cao*. Japanese Encephalitis Virus NS5 Inhibits the Type I Interferon Production by Blocking the Nuclear Translocation of IRF3 and NF-κB. Journal of Virology, 2017, 91(8): e00039-17.
3、Zhou D, Li Q, Jia F, Zhang L, Wan S, Li Y, Song Y, Chen H, Cao S, Ye J. The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS. J Immunol. 2020 Mar 1;204(5):1287-1298.
4、Chen B, Li C, Yao J, Shi L, Liu W, Wang F, Huo S, Zhang Y, Lu Y, Ashraf U, Ye J*, Liu X*. Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-κB. J Immunol. 2020 Apr 1;204(7):1881-1891.
5、 Zheng Chen, Xugang Wang, Usama Ashraf, Bohan Zheng, Jing Ye*, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao, Shengbo Cao*. Activation of neuronal N-methyl-D-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage. J Neuroinflammation. 2018 Aug 25;15(1):238.
6、Wang X, Zheng B, Ashraf U, Zhang H, Cao C, Li Q, Chen Z, Imran M, Chen H, Cao S, Ye J. Artemisinin inhibits the replication of flaviviruses by promoting the type I interferon production. Antiviral Res. 2020 Jul;179:104810.
7、Zikai Zhao; Mengying Tao; Wei Han; Zijing Fan; Muhammad Imran; Shengbo Cao; Jing Ye (*), Nuclear localization of Zika virus NS5 contributes to suppression of type I interferon production and response. Journal General Virology， 2019, doi: 10.1099/jgv.0.001376.
8、Muhammad Imran; Muhammad Kashif Saleemi; Zheng Chen; Xugang Wang; Dengyuan Zhou; Yunchuan Li; Zikai Zhao; Bohan Zheng; Qiuyan Li; Shengbo Cao (*); Jing Ye (*), Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses 2019; 11(11): 1011.
9、Yunchuan Li#, Hao Zhang#, Bibo Zhu, Usama Ashraf, Zheng Chen, Qiuping Xu, Dengyuan Zhou, Bohan Zheng, Yunfeng Song, Huanchun Chen, Jing Ye*, Shengbo Cao*. Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection. Frontiers in Immunology. 2017,8:1237.
10、Dengyuan Zhou, Fan Jia, Qiuyan Li, Luping Zhang, Zheng Chen, Zikai Zhao, Min Cui, Yunfeng Song, Huanchun Chen, Shengbo Cao, Jing Ye*. Japanese encephalitis virus NS1' protein antagonizes interferon beta production. Virol Sin. 2018 Dec 12.
11、Fang Zhang; Linlin Qi; Tong Li; Xiaojing Li; Dan Yang; Shengbo Cao; Jing Ye (*); Bin Wei (*), PD1+CCR2+CD8+ T Cells Infiltrate the Central Nervous System during Acute Japanese Encephalitis Virus Infection. Virologica Sinica, 2019; 34:538–548.
12、 Wen He, Zikai Zhao, Awais Anees, Yunchuan Li, Zheng Chen, Shengbo Cao, Yunfeng Song, Huanchun Chen, Jing Ye*. p21-activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus mediated Inflammation in Astrocytes. Front Cell Infect Microbiol. 2017,7:271.
13、Jing Ye#, Rong Jiang#, Min Cui, Bibo Zhu, Leqiang Sun, Yueyun Wang, Ali Zohaib, Qian Dong, Xindi Ruan, Yunfeng Song, Wen He, Huanchun Chen, Shengbo Cao*. Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. Journal of Infectious Diseases. 2014, 15; 210(6): 875-89.
14、Rong Jiang#, Jing Ye#, Bibo Zhu, Yunfeng Song, Huanchun Chen,Shengbo Cao*.Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia Following Japanese Encephalitis Virus Infection. Journal of Immunology Research, 2014, 2014：787023.
15、Jing Ye, Zheng Chen, Bo Zhang, Huan Miu, Ali Zohaib, Qiuping Xu, Huanchun Chen*, Shengbo Cao *. Heat shock protein 70 is associated with replicase complex of Japanese encephalitis virus and positively regulates viral genome replication. Plos One, 2013, 8(9): e75188.
16、Jing Ye, Bibo Zhu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*. Immune evasion strategies of flaviviruses. Vaccine, 2013, 31(3) : 461–471.
17、Yang Yang#, Jing Ye#, Xiaohong Yang, Rong Jiang, Huanchun Chen, Shengbo Cao*. Japanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain. Virology Journal 2011, 8:80
18、Yaoming Li#, Jing Ye#, Xiaohong Yang, Min Xu, Long Chen, Xueqin Liu, Huanchun Chen, Shengbo Cao*. Infection of mouse bone marrow-derived dendritic cells by live attenuated Japanese encephalitis virus induces cells maturation and triggers T cells activation. Vaccine, 2011, 29(4):855-862
19、Yaoming Li#, Jing Ye#, Shengbo Cao*, Shaobo Xiao, Qian Zhao, Xueqin Liu, Meilin Jin Huanchun Chen. Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice. Journal of Gene Medicine 2009, 11(1):57-65

科研项目

1. 动物传染病学，国家自然科学基金优秀青年基金，2021-2024，项目主持
2. 乙型脑炎病毒通过组蛋白H3K27me3修饰调控神经炎症的分子机制，国家自然科学基金面上项目，2020-2023，项目主持
3. 乙型脑炎病毒调控NMDA受体磷酸化及其介导神经损伤的分子机制，国家自然科学基金青年基金，2015-2018，项目主持
4. PAK4调控JEV诱导神经胶质细胞炎症反应的分子机制研究，博士后特别资助，2017-2019，项目主持
5. 乙型脑炎病毒通过激活NMDAR介导神经损伤的分子机制，博士后面上资助，2016-2018，项目主持
6. 非洲猪瘟等外来动物疫病防控科技支撑，国家重点研发计划，2019-2020，课题负责人
7. 重要神经嗜性人兽共患病免疫与致病机制研究，国家重点研发计划，2016-2020，研究骨干
8. 猪乙型脑炎高效疫苗与诊断试剂产业化，公益性行业专项， 2012-2016，研究骨干
9. 乙型脑炎病毒激活小胶质细胞的分子机制，国家自然科学基金面上项目，2012-2015，研究骨干

主要奖励

1. 2016年获湖北省科技进步一等奖，排名7