预防兽医学系

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  • 周红波
  • 系所

    预防兽医学系
  • 职称

    教授
  • 办公房间

    农业微生物学国家重点实验室A座F101
  • 电子邮件

    hbzhou@mail.hzau.edu.cn
  • 讲授课程

    《动物传染病学》、《动物传染病学实验》、《细胞生物学》等

个人简介

周红波,男,湖北武汉人。华中农业大学教授、博士生导师。湖北省杰出青年基金获得者,入选武汉市晨光计划。于2000年和2006年在华中农业大学分别获兽医本科和博士学位,师从陈焕春院士。2006年-2008年在农业微生物学国家重点实验室从事博士后研究。2011年-2013年在英国帝国理工学院从事博士后研究,师从流感病毒国际权威专家Wendy Barclay教授。2013年晋升为教授。先后主持了国家自然科学基金(4项)、国家重点研发计划、973项目、湖北省杰出青年基金、湖北省重大科技创新计划等项目。获国家科技进步二等奖2项(排五,2011年,排八,2016年),湖北省科技进步一等奖1项(排三,2015年),湖北省自然科学优秀论文二等奖1项,获得国家发明专利6项,新兽药注册证书2项。在Emerging Infectious Diseases, Journal of Infectious Diseases, Journal of Virology等国际重要刊物上发表SCI研究论文30余篇。兼Virulence,PLoS ONE,Biomedical and Environmental Sciences,Virology Journal等多家SCI期刊的审稿人。

教育经历

1996.09 - 2000.06, 华中农业大学,兽医学专业毕业,学士
2000.09 - 2003.06, 华中农业大学,兽医学专业毕业,硕士
2003.09 - 2006.06, 华中农业大学,兽医学专业毕业,博士

工作经历

2006/7-2008/12,华中农业大学,农业微生物学国家重点实验室,博士后
2008/12-2011/8,华中农业大学,动物科技学院-动物医学院,副教授
2011/8-2013/10,英国帝国理工学院,博士后,合作导师:Wendy Barclay
2013/12-至今,华中农业大学,动物科技学院-动物医学院,教授,博士生导师

研究领域

(1)动物流感病毒致病、免疫及跨种感染的分子机理
(2)流感病毒基因工程疫苗的分子设计与创制
(3)流感病毒新型诊断制剂的研制和抗流感病毒药物筛选

科研成果

A著作类
1. 参译《Veterinary Pharmacology and Therapeutics,9th》,中国农业出版社,国际最新版通用教材,2011
2. 参编《猪流感》及《关注人兽共患病 关爱人类健康》著作2部。
B论文类
1. Proteomic analysis of chicken embryo fibroblast cells infected with recombinant H5N1 avian influenza viruses with and without NS1 eIF4GI binding domain. Oncotarget, 2017.11.
2. Identification and characterization of a protective antigen, PlpB of bovine Pasteurella multocida strain LZ-PM. Dev Comp Immunol. 2017 Jun;71:1-7.
3. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS, Respectively. Int J Mol Sci. 2017 Apr 3;18(4).
4. Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Scientific Reports, 2017 Jan 12;7:40698.
5. Molecular cloning and functional analysis of the duck TIR domain-containing adaptor inducing IFN-β (TRIF) gene. Dev Comp Immunol. 2016 Dec;65:369-76.
6. Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells. Sci Rep. 2015 Oct 9;5:14991.
7. Glycosylation on Hemagglutinin Affects the Virulence and Pathogenicity of Pandemic H1N1/2009 Influenza A Virus in Mice. PLoS ONE 2013 Apr 24;8(4):e61397.
8. Genetic Characterization of H1N2 Swine Influenza Virus Isolated in China and Its Pathogenesis and Inflammatory Responses in Mice. Arch Virol 2013 Sep;158(9):1965-72.
9. Pandemic (H1N1) 2009 Virus in Swine Herds, People’s Republic of China. Emerging Infectious Diseases 2011 Sep, 9:17.
10. Response of swine lung to H1N1 swine influenza virus infection revealed by transcription analysis. BMC Genomics 2011, 12:398.
11. Emergence of Novel Reassortant H3N2 Influenza Viruses among Ducks in China. Arch Virol 2011 156:1045-1048.
12. Effect on Virulence and Pathogenicity of H5N1 Influenza A Virus through Truncations of NS1 eIF4GI Binding Domain. Journal of Infectious Diseases 2010 Nov 1; 202(9): 1338-46.
13. The Special neuraminidase Stalk-Motif Responsible for Increased Virulence and Pathogenesis of H5N1 Influenza A Virus. PLoS ONE 2009, 17; 4(7): e6277.
14. Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Arch Virol 2009, 154:887-890.
15. Effect Small Interfering RNAs Targeting Matrix (M2) and Nucleocapsid Protein (NP) Gene Inhibits Influenza A Virus Replication in Cells and Mice. Antiviral Research 2007, (76): 186-193.
16. Genome Sequence Analysis of the Pathogenic H5N1 Avian Influenza A Virus Isolated in China in 2004. Virus Genes 2006, 32: 85-95.
17. Duck interferon regulatory factor 1 acts as a positive regulator in duck innate antiviral response. Dev Comp Immunol. 2018 Jan;78:1-13.16.
18. The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-β Production by Targeting TNF Receptor-Associated Factor 3. Front Immunol. 2017 Jul 3;8:779.
19. HIST1H1C Regulates Interferon-β and Inhibits Influenza Virus Replication by Interacting with IRF3. Front Immunol. 2017 Mar 24;8:350.
20. Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses. Sci Rep. 2017 Mar 6;7:43566.
21. Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA. J Immunol. 2016 Dec 15;197(12):4704-4713.
22. 14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1) influenza viruses. Antiviral Res. 2016 Sep;133:95-105.
23. Molecular cloning and functional analysis of duck ubiquitin-specific protease 18 (USP18) gene. Dev Comp Immunol. 2016 Sep;62:39-47.
24. 14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes. Antiviral Res. 2015 Jun;118:82-92.
25. Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-β production. Dev Comp Immunol. 2015 May;50(1):49-57.
26. CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2. Cell Mol Life Sci. 2015 Mar;72(5):971-82.
27. The 2009 pandemic (H1N1) viruses isolated from pigs show enhanced pathogenicity in mice. Vet Res. 2013 Jun 11;44:41.
28. Investigation of influenza virus polymerase activity in pig cells. J Virol. 2013 Jan;87(1):384-94.
29. Identification of human host proteins contributing to H5N1 influenza virus propagation by membrane proteomics. J Proteome Res. 2012 Nov 2;11(11):5396-405.
30. The antigenic property of the H5N1 avian influenza viruses isolated in central China. Virol J. 2012 Aug 6;9:148.
31. Analysis of cellular proteome alterations in porcine alveolar macrophage cells infected with 2009 (H1N1) and classical swine H1N1 influenza viruses. J Proteomics 2011 Dec 20.
32. Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression. PLoS ONE 2011, 6(10): e26175.
33. Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells. Virol J 2011 May 19; 8:240.
34. Proteomics analysis of differential expression of chicken brain tissue proteins in response to neurovirulent H5N1 avian influenza virus infection. J Proteome Res 2010 May 3.
35. Genetic characterization of an H5N1 avian influenza virus with neurovirulence in ducks. Virus Genes 2009, 38(2): 263-8.
36. Evolutionary characterization of influenza virus A/duck/Hubei/W1/2004 (H9N2) isolated from central China. Virus Genes 2008, 36(1):79-83.
37. Generation and Characterization of an H5N1 Avian Influenza Virus Hemagglutinin Glycoprotein Pseudotyped Lentivirus. Journal of Virological Methods 2008, 154: 99-103.
38. Avian Influenza (H5N1) Virus in Waterfowl and Chickens, Central China. Emerging Infectious Diseases 2007, 13(5): 772-775.

科研项目

1. 国家自然科学基金面上项目,核仁蛋白LYAR调控流感病毒复制的分子机制研究 2018-2021。
2. 国家重点研发计划,动物流感病毒遗传变异与致病机理研究,2016-2020。
3. 国家重点研发计划,重要新发突发病原体发生与播散机制研究,2016-2020。
4. 国家自然科学基金面上项目,流感病毒核输出蛋白调控病毒vRNA,cRNA和mRNA合成的分子机制研究,2016-2019。
5. 湖北省杰出青年基金,猪流感病毒复制相关宿主细胞因子的发掘及功能研究,2017-2019。
6. 武汉市青年科技晨光计划,H9亚型禽流感病毒检测方法的建立及应用,2015-2017。
7. 湖北省重大科技创新计划,规模化鸡场重要流行性疫病综合防控关键技术研发,2015-2017。
8. 国家自然科学基金面上项目,H1亚型猪流感病毒毒力变异和致病的分子机制研究,2011-2013。
9. 中央高校优秀人才培育项目,动物流感病毒致病机制与防制技术研究,2011-2013。
10. 973项目,流感病毒重组机制研究,2010-2011。
11. 国家自然科学基金青年科学基金项目,猪流感病毒NA和NS1基因部分区段的基因功能定位研究,2009-2011。

主要奖励

(1) 周红波(8/10),我国重大猪病防控技术创新与集成应用,中华人民共和国国务院,国家科技进步二等奖,2016.12.21
(2) 周红波(3/14),猪流感病毒致病机制与防控技术,湖北省科技厅,湖北省科技进步一等奖,2015.8.31
(3) 周红波(1/7),Pandemic (H1N1) 2009 virus in swine herds, People's Republic of China,湖北省科技厅,湖北省自然科学优秀论文奖,二等,2012.12.1
(4) 周红波(5/10),动物流感系列快速检测技术的建立及应用,中华人民共和国国务院,国家科技进步二等奖,2011.12.23
(5) 湖北省优秀硕士学位论文指导教师奖,湖北省教育厅,2014.12.31

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