预防兽医学系

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  • 贺兰
  • 系所

    预防兽医学系
  • 职称

    七级副教授
  • 办公房间

    农业微生物学国家重点实验室A312
  • 电子邮件

    helan@mail.hzau.edu.cn
  • 讲授课程

    《动物寄生虫病学A》、《动物寄生虫病学实验》、《寄生虫病诊断技术》等

个人简介

贺兰,女,湖北大冶人。华中农业大学副教授、硕士生导师。分别于2006年、2011年毕业于华中农业大学动物医学院,获得农学学士学位和农学博士学位。2008年和2009年留学南非比勒陀利亚大学兽医学院,主要学习蜱传性疾病的临床检测;2011年9月至2013年3月在美国德州理工大学健康科学中心从事博士后研究;2014年1月在华中农业大学动物医学院工作;2016年访学美国德州农工大学。一直专注于巴贝斯虫相关研究,已从事东方巴贝斯虫基因组学、入侵机制、疫苗的开发、早期诊断抗原和药物靶标的筛选等工作近10年,尤其是巴贝斯虫诊断方面,致力于早期分泌抗原的筛选,研发了多种可用于实验室、临床、宠物医院等不同条件不同需求的快速诊断方法。先后主持过国家自然科学基金青年基金、面上基金、十三五重点研发计划、中国博士后基金、973技术骨干、华中农业大学国际合作培育项目等。发表SCI收录论文近30篇,其中包括Frontiers in Microbioology, Parasites & Vecters, Vet. Parasitol等;获国家发明专利1项,申报国家发明专利3项,参编著作1部。

教育经历

2006/09 – 2011/06 华中农业大学预防兽医学,博士
2009/09 – 2009/12 南非比勒陀利亚大学兽医学院,合作课题交流
2008/10 – 2009/01 南非比勒陀利亚大学兽医学院,合作课题交流
2002/09 – 2006/07 华中农业大学动物医学院,学士

工作经历

2016/1 – 至今 华中农业大学动物医学院,副教授
2014/1 – 2015/12 华中农业大学动物医学院,副研究员
2011/08 – 2013/12 华中农业大学动物科技学院
2011/09 – 2013/3 美国德州理工大学健康科学中心

研究领域

巴贝斯虫基因组学、入侵机制、疫苗的开发、早期诊断抗原和药物靶标的筛选

科研成果

B论文类
He L., Miao XY., Hu JF., Huang Y., He P., He JW., Yu L., Malobi N., Shi LG., Zhao JL. First molecular detection of Babesia gibsoni in dogs from Wuhan, China. Frontiers in Microbiogy. doi.org/10.3389/fmicb.2017.01577.
He L., Liu Q., Yao BA., Zhou YQ., Hu M., Fang R., Zhao JL. A historical overview of research on Babesia orientalis, a protozoan parasite infecting water buffalo. Frontiers in Microbiogy. doi.org/10.3389/fmicb.2017.01323.
Ngabu Malobi, He L*, Yu L, He P, He J, Sun Y, Huang Y, Zhao J*. Molecular cloning and characterization of Babesia orientalis Rhoptry Neck 2 BoRON2 protein. J. Parasitol. Res. 2017; 2017:7259630. doi: 10.1155/2017/7259630. Epub 2017 Jul 9.
Huang Y, He L*, Hu J, Miao XY, He P, He JW, Yu L, NgabuMalobi, Zhou YQ, Shen B, Zhao JL*. Characterization and annotation of Babesia orientalis apicoplast genome. Parasites & Vectors. 2015 Oct 16;8(1):543.
He L, Fan LZ, Liu Q, Hu J, Miao XY, Huang Y, He P, He JW, Yu L, Muhammad K,Zhou YQ, Shen B, Zhao JL.Identification and characterization of a novel 34 kDamerozoite protein in Babesia orientalis. Vet. Parasitol. 2015, Sep 15;212(3-4):411-6. doi:10.1016/j.vetpar.2015.06.031
He L, Fan LZ, Hu JW, Miao XY, Huang Y, Zhou YQ, Hu M, Zhao JL.Characterisation of a Babesiaorientalis apical membrane antigen, and comparison of its orthologues among selected apicomplexans. Ticks Tick Borne Dis. 2015 6:290-296
Yu Q, He L*, Zhang WJ, Cheng JX, Hu JF, Miao XY, Huang Y, Fang LZ, Muhammad Kasib Khan, Zhou YQ, Hu M, Zhao JL*. Molecular cloning and characterization of Babesia orientalis rhoptry-associated protein 1. Vet. Parasitol. 2014, 205:499-505.
He L, YuQ, ZhangWJ, ZhangQL, FanLZ, MiaoXY, Muhammad KK, HuM, ZhouYQ, Zhao JL*. Molecular cloning and characterization of a novel heat shock protein 20 of Babesiaorientalis. Vet. Parasitol. 2014, 204:177-183.
He L, Zhang Y, Zhang QL, Zhang WJ, Feng HH, Muhammad KK, Hu M, Zhou YQ, Zhao JL*. Mitochondrial genome of Babesiaorientalis, apicomplexan parasite of water buffalo (Bubalusbabalus, Linnaeus, 1758) endemic in China. Parasites & Vectors 2014. 7:82. doi:10.1186/1756-3305-7-82.
Khan MK, He L, Zhang W, Wang Y, Tao Q, Song Q, Sajid MS, Yu Q, Hu J, Fang R, Hu M, Zhou Y, Zhao J. Identification of two novel HSP90 proteins in Babesia orientalis: molecular characterization, and computational analyses of their structure, function, antigenicity and inhibitor interaction. Parasites & Vectors 2014. 7:293. doi: 10.1186/1756-3305-7-293.
Song WJ, Song QQ, He L, Zhou YQ, Zhao JL. The establishment and application of a semi-nested PCR assay for the detection of Mycoplasma ovis. Small Ruminant Research. 2014, 119 (1-3): 176-181.
Song Q, Zhang W, Song W, Liu Z, Khan MK, He L, Fang R, Li P, Zhou Y, Hu M, Zhao J. Seroprevalence and risk factors of Mycoplasma suis infection in pig farms in central China. Prev Vet Med. 2014 Nov 1;117(1):215-21.
Muhammad Kasib Khan, Muhammad SohailSajid, Hasan Riaz, Nazia Ehsan Ahmad, He L, et al. The global burden of fasciolosis in domestic animals with an outlook on the contribution of new approaches for diagnosis and control. Parasitol. Res. 2013, 2421 – 2430.
Muhammad Kasib Khan, He L, Altaf Hussain, SabitaAzam, Zhang WJ, Wang LX, Zhang QL, Hu M, Zhou YQ, Zhao JL*. Molecular epidemiology of Theileriaannulata and identification of 18S rRNA gene and ITS regions sequences variants in apparently healthy buffaloes and cattle in Pakistan. Infection Genetics Evolution. 2013, 13: 124 – 132.
He L, ZhouYQ, Fang R, Feng H, Wang LX, Tu P, Marinda C. Oosthuizen, Zhao JL*. Occurance of Theileria and Babesia species in water buffalo (Bubalusbabalis, Linnaeus, 1758) in the Hubei province, South China. Veterinary Parasitology. 2012, 186: 490 – 496.
He L, MuhanmadKasib Khan, ZhangWJ, ZhangQL, ZhouYQ, HuM, ZhaoJL*. Detection and identification Theileria infectious in sika deer (Cervus Nippon) in China.The Journal of Parasitology. 2012, 98: 598 – 603
HeL, FengHH, ZhangQL, ZhangWJ, MuhanmadKasib Khan, HuM, ZhouYQ, ZhaoJL*. Development and evaluation of real-time PCR assay for the detection of Babesiaorientalis in water buffalo (Bubalusbubalis, Linnaeus, 1758). The Journal of Parasitology. 2011, 97: 1166 – 1169.
WangLX, He L, FangR, SongQQ, TuP, ZhouYQ, ZhaoJL*. Loop-mediated isothermal amplification (LAMP) assay for detection of Theileriasergenti infection targeting the p33 gene. Veterinary Parasitology. 2010, 171:159-162.
He L, ZhouYQ, Marinda C. Oosthuizen, ZhaoJL*. Loop-mediated isothermal amplification (LAMP) detection of Babesiaorientalis in water buffalo (Bubalusbabalis, Linnaeus, 1758) in China. Veterinary Parasitology. 2009, 165: 36-40.
HeL, Liu Q, Melvyn Quan, Zhou DN, Zhao JL. Molecular cloning and phylogenetic analysis of Babesiaorientalis heat shock protein 70. Veterinary Parasitology. 2009, 162:183-191.
Fang R, Nie H, Wang ZS, Tu P, Zhou DN, Wang LX, He L, Zhou YQ, Zhao JL*. Protective immune response in BALB/c mice induced by a suicidal DNA vaccine of the MIC3 gene of Toxoplasma gondii. Veterinary Parasitology. 2009, 164:134-140.
Wang LX, Zhao LH, He L, Liu Q, Zhou DN, Zhou YQ, Zhao JL*. An indirect ELISA for detection of Theileriasergenti antibodies in water buffalo using a recombinant major piroplasm surface protein, Veterinary Parasitology. 2008, 170:323-326.

科研项目

1.严重危害畜禽生产重要寄生虫诊断标识发掘与鉴定。 2017.07-2021.12.
2. 1-脱氧-D-木酮糖-5-磷酸还原异构酶在东方巴贝斯虫中的功能研究,2018-2021.
3. 寄生虫侵入的关键分子与功能,2015-2019。

主要奖励

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