个人简介

魏泓，男，四川泸州人。华中农业大学教授、博士生导师，兼任中国实验动物学会无菌动物专业委员会主任委员。致力于以遗传工程和无菌动物技术为核心，以解析机体自身基因组功能和肠道菌群宏基因组功能及其相互关系为学术目标，形成了模型动物制备与应用创新研究体系。建立了国内最具影响力无菌动物平台，形成了无菌与有菌动物比较、菌群（菌株）移植、遗传工程动物无菌化、无菌动物发育的四种基本研究模式，为抑郁、精神分裂症、结肠癌、乳腺炎、肠道肥大细胞溶菌酶释放等重大疾病发生发展、重要生理病理表型与肠道菌群因果关系确立发挥了重要作用，有效支撑了国内医学、食品、畜牧等领域微生物组动物实验研究。建立了小型猪遗传工程技术体系，开展巴马香猪在疾病模型、生物材料、药物评价的应用研究。创制了基因敲出、定向敲入、单碱基突变等系列基因编辑小型猪新模型。创制血清白蛋白人源化转基因猪。利用ENU化学诱变技术创制sox10、kit基因突变耳聋猪等疾病家系。承担无菌动物及遗传工程猪模型973、863、国家自然科学基金等课题，获科研经费4千余万元。在Science等期刊发表SCI论文88篇，以(共同)通讯作者在Nature Immunology、Molecular Psychiatry 、Gastroenterology、Blood、Science Advances、 Microbiome、 Elife等期刊发表SCI论文61篇，授权发明专利17项。以第一完成人获全军优秀教学成果一等奖“医学实验动物学课程的创建与实践”。主编“医学实验动物学”为国家教育部首批推荐全国研究生教学用书、主编《医学动物实验技术》获国家科学技术学术著作出版基金资助。先后培养博士、硕士80余名。

教育经历

1979.9-1983.7，西南农业大学兽医专业，学士
1985.9-1988.7，东北农业大学兽医病理学专业，硕士
1992.9-1996.7，第三军医大学（中国人民解放军陆军军医大学）病理解剖学专业，博士

工作经历

1988.7-1993.6 中国人民解放军陆军军医大学基础医学院，讲师
1993.7-1998.6 中国人民解放军陆军军医大学基础医学院，副教授
1998.7-今中国人民解放军陆军军医大学基础医学院，教授，主任
2018.8-今华中农业大学动科动医学院，特聘教授

研究领域

小型猪遗传工程技术、无菌动物技术与畜禽微生物组研究等。

科研成果

A著作类
1.《医学动物实验技术》，2012年国家科学技术学术著作出版基金资助,人民卫生出版社，2016，主编
2.《医学实验动物学》，国家教育部首批审定的全国研究生教学用书，四川科学技术出版社，1998，主编
3.《实验动物学》（第二版），全国高等学校长学制临床医学专业第三轮国家卫生和计划生育委员会规划教材，人民卫生出版社，2015，共同主编
4.《实验动物学》，全国高等学校八年制临床医学专业卫生部规划教材, 人民卫生出版社， 2010，副主编
5.《感染微生态学》人民卫生出版社，2012，参编
6.Science增刊Regenerative Medicine in China中的Promoting wound healing in burn patients：pig-derived tissues, S. Sanders Ed. (Science/AAAS, Washington, DC, 2012), pp.40-41，参编(并列通讯作者)
7.Skin grafts-indications, applications and current research 中的Chapter 13 Skin graft preservation，In Tech出版社，2011，参编
8.2008-2009实验动物学学科发展报告，中国科学技术出版社，2009，参编
B论文类
1.Li B, Ge Y, Cheng L, Zeng B, Yu J, Peng X, Zhao J, Li W, Ren B, Li M, Wei H, Zhou X. Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice. Int J Oral Sci. 2019 Mar 5;11(1):10. doi: 10.1038/s41368-018-0043-9. [共同通讯作者，IF: 4.138]
2.Peng Zheng ,Benhua Zeng , Meiling Liu , Jianjun Chen , Junxi Pan ,Yu Han ,Yiyun Liu , Ke Cheng , Chanjuan Zhou , Haiyang Wang , Xinyu Zhou , Siwen Gui ，Seth W. Perry , Ma-Li Wong 8, Julio Licinio , Hong Wei , Peng Xie . The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. SCIENCE ADVANCES, 2019; 5 : eaau8317.[共同通讯作者，IF:11.5]
3.Ma C, Sun Z, Zeng B, Huang S, Zhao J, Zhang Y, Su X, Xu J*, Wei H* and Zhang H*. Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis. Microbiome. 2018, 6:200. [共同通讯作者，IF: 9.133]
4.Luo Y#, Zeng B#, Zeng L#, Du X#, Li B, Huo R, Liu L, Wang H, Dong M, Pan J, Zheng P, Zhou C, Wei H*, Xie P*. Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus. Transl Psychiatry. 2018 Sep 7;8(1):187. [共同通讯作者，IF: 4.691]
5.Hao QQ#, Li L#, Chen W, Jiang QQ, Ji F, Sun W, Wei H*, Guo WW*, Yang SM*. Key Genes and Pathways Associated With Inner Ear Malformation in SOX10 (p.R109W) Mutation Pigs. Front Mol Neurosci. 2018 Jun 5;11:181. [共同通讯作者，IF: 3.902]
6.Wu H, Zeng B, Li B, Ren B, Zhao J, Li M, Peng X, Feng M, Li J, Wei H#, Cheng L#, Zhou X#. Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study. Sci Rep. 2018, 8;8(1):7267. [共同通讯作者，IF: 4.259]
7.Banru Chen, Xiang Ni, Rui Sun, Benhua Zeng, Hong Wei#, Zhigang Tian#, Haiming Wei#. Commensal bacteria-dependent CD8αβ+ T cells in the intestinal epithelium produce antimicrobial peptides. Frontiers in Immunology. 2018, DOI: 10.3389/fimmu.2018.01065. [共同通讯作者，IF: 6.429]
8.Wang L*, Zeng B*, Liu Z, Liao Z, Zhong Q, Gu L, Wei H#, Fang X#. Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High-Fat Diet Treated HFA Mice. J Food Sci. 2018, 83(3):864-873. [共同通讯作者，IF: 1.815]
9.Li B*, Guo K*, Zeng L*, Zeng B*, Huo R, Luo Y, Wang H, Dong M, Zheng P, Zhou C, Chen J, Liu Y, Liu Z, Fang L, Wei H*, Xie P*. Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers. Translational Psychiatry. 2018,31;8(1):34. doi: 10.1038/s41398-017-0078-2. [共同通讯作者，IF: 4.73]
10.Huo R#, Zeng B#, Zeng L#, Cheng K#, Li B, Luo Y, Wang H, Zhou C, Fang L, Li W, Niu R, Wei H*, Xie P*, Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis. Front. Cell. Infect. Microbiol. 7:489. doi: 10.3389/fcimb.2017.00489. [共同通讯作者，IF: 4.3]
11.Hai T#, Guo W#, Yao J#, Cao C, Luo A, Qi M, Wang X, Wang X, Huang J, Zhang Y, Zhang H, Wang D, Shang H, Hong Q, Zhang R, Jia Q, Zheng Q, Qin G, Li Y, Zhang T, Jin W, Chen ZY, Wang H, Zhou Q, Meng A, Wei H*, Yang S*, Zhao J*. Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis.. Human genetics,2017. doi: 10.1007/s00439-017-1851-2. [共同通讯作者，IF: 5.34]
12.Zhang Y#, Xue Y#, Cao C#, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi G, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H*, Liu F*, Zhao J*. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017.doi: 10.1182/blood-2017-05-783043. [共同通讯作者，IF: 13.164]
13.Sunny H Wong#, Liuyang Zhao#, Xiang Zhang, Geicho Nakatsu, Juqiang Han, Weiqi Xu1, Xue Xiao, Thomas NY Kwong, Ho Tsoi, William KK Wu, Zeng Benhua, Francis KL Chan, Joseph JY Sung, Hong Wei*, Jun Yu*, Gavage of Fecal Samples From Patients with Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-free and Conventional Mice, Gastroenterology, 2017. [共同通讯作者，IF: 18.392]
14.Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. A pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017 doi: 10.7554/eLife.26248. [共同通讯作者，IF: 8.282]
15.Geng X, Li W, Shang H, Gou Q, Zhang F, Zang X, Zeng B, Li J, Wang Y, Ma J, Guo J, Jian J, Chen B, Qiao Z, Zhou M, Wei H*, Fang X*, Xu C*. A reference gene set construction using RNA-seq of multiple tissues of Chinese Giant Salamander, Andrias davidianus. Gigascience. 2017, doi: 10.1093/gigascience/gix006. [共同通讯作者，IF:7.463]
16.Chen JJ, Zeng BH, Li WW, Zhou CJ, Fan SH, Cheng K, Zeng L, Zheng P, Fang L, Wei H*, Xie P*. Effects of gut microbiota on the microRNA and mRNA expression in the hippocampus of mice. Behav Brain Res. 2017, 322(Pt A):34-41. doi:10.1016/ j.bbr.2017.01.021. [共同通讯作者，IF: 3.002]
17.Yong Wang, Yinnan DU, Xiaoyang Zhou, Lulu Wang, Jian Li, Fengchao Wang,Zhengen Huang, Xingxu Huang, Hong Wei. Efficient generation of B2m-nullpigs via injection of zygote with TALENS. Sci Rep. 2016 , 6:38854. doi: 10.1038/srep38854 . [通讯作者，IF: 5.228]
18.Diao H, Yan HL, Xiao Y, Yu B, Yu J, He J, Zheng P, Zeng BH, Wei H*, Mao XB*, Chen DW*. Erratum to: Intestinal microbiota could transfer host Gut characteristics from pigs to mice. BMC Microbiol. 2016, 16(1):253. [共同通讯作者，IF:2.582]
19.Wang L, Zeng B, Zhang X, Liao Z, Gu L, Liu Z, Zhong Q, Wei H*, Fang X*. The effect of green tea polyphenols on gut microbial diversity and fat deposition in C57BL/6J HFA mice. Food Funct. 2016, 7(12):4956-4966. [共同通讯作者，IF: 2.686]
20.Yan H, Diao H, Xiao Y, Li W, Yu B, He J, Yu J, Zheng P, Mao X, Luo Y, Zeng B, Wei H*, Chen D*. Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice. Sci Rep. 2016, 6:31786. doi: 10.1038/srep31786. [共同通讯作者，IF: 5.228]
21.Liu X, Zeng B, Zhang J, Li W, Mou F, Wang H, Zou Q, Zhong B, Wu L, Wei H*, Fang Y*. Role of the Gut Microbiome in Modulating Arthritis Progression in Mice. Sci Rep. 2016, 6:30594. doi: 10.1038/srep30594. [共同通讯作者，IF: 5.228]
22.Zeng L, Zeng B, Wang H, Li B, Huo R, Zheng P, Zhang X, Du X, Liu M, Fang Z, Xu X, Zhou C, Chen J, Li W, Guo J, Wei H*, Xie P*. Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling. Sci Rep. 2016, 6:29998. doi: 10.1038/srep29998. [共同通讯作者，IF: 5.228]
23.Zheng P, Zeng B, Zhou C, Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, Melgiri ND, Licinio J, Wei H*, Xie P. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism. Mol Psychiatry. 2016, 21(6):786-96. doi: 10.1038/mp.2016.44. [共同通讯作者，IF: 13.314]
24.Shibin Zhang, Kenan Guo, Dying Kong, Yu Liu, Haitao Shang, Hong Wei. Semen quality and fertility of Bama miniature pig (Susscrofadomestica). India Journal of Animal Research. 2016, 50(3): 434-6.[通讯作者，IF: 0.044] 25.Shibin Zhang, Kenan Guo, FeiXie, Yu Liu, Haitao Shang, Hong Wei. The normal electrocardiograms of Bama miniature pigs (Susscrofadomestica). JAALAS. 2016, 55(2):152-154. [通讯作者，IF: 1.115]
26.Zhou X, Wang L, Du Y, Xie F, Li L, Liu Y, Liu C, Wang S, Zhang S, Huang X, Wang Y, Wei H. Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes. Hum Mutat. 2015. doi: 10.1002/humu.22913. [通讯作者，IF: 5.144]
27.Qing-hua WANG, Yun PENG, Xin-yong CAI, Meng WAN, Yu LIU, Hong WEI. The Nucleus Transfer Vigor of Ear Fibroblast Cells Isolated from Bama Miniature Pig at the Various Ages. Journal of Huazhong University of Science and Technology Medical Sciences, 2015.35(4):585-590. [共同通讯作者，IF: 0.834]
28.Q. H. Wang J. Y. Chen, K. N. Guo, X. B. Zheng, Q. Wu, H. Wei*,Y. Liu*. A Correlation Study of Boar taint-Related Genes, Boar Taint Substances, and Sex Hormones in Bama Miniature Pigs at Different Ages. Indian Journal of Animal Research,2015, DOI: 10.18805/ijar.5962.[ 共同通讯作者，IF: 0.044]
29.Peng J, Wang Y, Jiang J, Zhou X, Song L, Wang L, Ding C, Qin J, Liu L, Wang W,Liu J, Huang X, Wei H*, Zhang P*. Production of Human Albumin in Pigs ThroughCRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in theZygotes. Sci Rep. 2015, 5:16705. doi: 10.1038/srep16705.[共同通讯作者，IF: 5.578]
30.Bian Y, Yao Q, Shang H, Lei J, Hu H, Guo K, Jiang H, Yu L, Wei H*, Zeng S*.Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the CatalyticCharacteristics with Each Other and Their Liver Microsomes. Drug MetabDispos.2015, 43(9):1336-40. [共同通讯作者，IF: 3.334]
31.Zhang Q, Pan Y, Yan R, Zeng B, Wang H, Zhang X, Li W, Wei H*, Liu Z*. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat Immunol. 2015, 16(9):918-26.[ 共同通讯作者，IF: 20.004 ]
32.Wang Y, Yang HQ, Jiang W, Fan NN, Zhao BT, Ou-Yang Z, Liu ZM, Zhao Y, Yang DS, Zhou XY, Shang HT, Wang LL, Xiang PY, Ge LP, Wei H*, Lai LX*. Transgenic expression of human cytoxic T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting. Transgenic Res. 2015, 24(2):199-211. [通讯作者，IF:2.609]
33.Wang Y, Du Y, Shen B, Zhou X, Li J, Liu Y, Wang J, Zhou J, Hu B, Kang N, Gao J, Yu L, Huang X, Wei H. Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. Sci Rep. 2015, 5:8256.[通讯作者，IF: 5.078] 34.Chongli Xu, Yu Liu, Yuchen Gong, XinpingDuan, Xiaochun Tang, Mingjun Zhang, Daxin Pang, Liqing Yu, Hong Wei*, Hongsheng Ouyang*. Overexpression of NPC1L1 in the livers of transgenic Bama miniature pigs accelerates lipid peroxidation. Genes Genom. 2014, DOI 10.1007/s13258-014-0235-4. [共同通讯作者，IF=0.565]
35.Zhang X, Zeng B, Liu Z, Liao Z, Li W, Wei H*, Fang X*. Comparative diversityanalysis of gut microbiota in two different human flora-associated mouse strains.CurrMicrobiol. 2014,69(3):365-73. [通讯作者，IF=1.52].
36.Wang Y, Zhou XY, Xiang PY, Wang LL, Tang H, Xie F, Li L, Wei H. The meganuclease I-SceI containing nuclear localization signal (NLS-I-SceI) efficiently mediated mammalian germline transgenesis via embryo cytoplasmic microinjection. PLoS One. 2014,9(9):e108347. [通讯作者，IF: 3.534]
37.Shang H, Guo K, Liu Y, Yang J, Wei H. Constitutive expression of CYP3A mRNA in Bama miniature pig tissues. Gene. 2013. 524(2): 261-7. [通讯作者，IF: 2.196]
38.Xie CH, Zhang L, Zeng BH, Yuan J, Tang H, Wei H.Hypercholesterolemia in pregnant mice increases the susceptibility to atherosclerosis in adult life. Vascular 2013 Jun 18. [通讯作者，IF: 0.86]
39.Liu X, Zou Q, Zeng B, Fang Y*, Wei H*.Analysis of fecal Lactobacillus community structure in patients with early rheumatoid arthritis.CurrMicrobiol. 2013, 67(2):170-6. [共同通讯作者，IF=1.52]
Zeng B, Li G, Yuan J, Li W, Tang H, Wei H. Effects of age and strain on the microbiota colonization in an infant human flora-associated mouse model. CurrMicrobiol. 2013 Sep;67(3):313-21.[通讯作者，IF: 1.52]

科研项目

1. 以肠道菌群为靶点的拟人化仓鼠冠心病模型建立；国家自然科学基金面上项目2018.01
2. 基于无菌小鼠模型研究肠道菌群在胃转流手术治疗糖尿病中的作用；国家自然科学基金面上项目2014.01
3. 小型猪CYP药物代谢动物模型关键问题基础研究；国家自然科学基金面上项目2012.01
4. 人源化抗体转基因动物的联合研发；科技部项目2013.01
5. 基于组学策略研究EGCG在人源菌群小鼠结肠的代谢通道；国家自然科学基金面上项目（合作）2018.01
6. 人源菌群小鼠结肠多样性与脂肪代谢对饮食变化的响应；国家自然科学基金面上项目（合作）2011.01
7. 肠道菌群失调在脾虚湿困型类风湿关节炎发病中的作用与机制研究；国家自然科学基金面上项目（合作）2011.01
8. 幽门螺杆菌感染与胃内菌群结构及功能的关系研究；国家自然科学基金面上项目（合作）2011.01
9. 小型猪和小鼠等医学实验哺乳动物模型建立与基础数据集成；国家重点基础研究发展计划（973计划子课题） 2011.01
10. 重大疾病动物模型制作与评价体系研究；国家科技支撑计划（合作）2011.01
11. 诱导多功能干细胞（iPS）猪与小型猪疾病模型；科技部项目 2011.01
12. 感染微生态动物模型的建立、评价及应用；科技部973课题 2007.01
13. 益生菌定向筛选关键技术及产品开发研究；科技部863课题 2007.01
14. 抗生素残留引起细菌耐药性安全评价技术研究；科技部子课题 2006.01
15. 壳多糖和动物源性材料组织工程皮肤关键技术的研究；科技部项目 2006.01
16. 小鼠疾病模型资源、数据或信息共享网络的建立和应用示范；科技部项目 2006.01
17. 中国实验用小型猪资源开发和研究应用；科技部项目 2004.01
18. 异种皮肤移植转基因小鼠模型的研究；科技部项目 2003.01
19. 中国三种实验用小型猪遗传监测及近交培育的研究；国家自然科学基金面上项目1998.01
20. 中国三种实验用小型猪遗传检检测标准的建立；科技部项目 1997.01

主要奖励

1. 重庆市研究生教育优质课程（实验动物学，2013，排名第一）
2. 重庆市科技进步二等奖（医用小型猪标准化、应用关键技术及重要特性研究，2011，排名第一）
3. 首届中国实验动物学会科学技术二等奖（医用小型猪标准化、应用关键技术及重要特性研究，2010，排名第一）
4. 重庆市科技进步二等奖（高等级实验动物生产技术研究及基地建设，2009，排名第三）
5. 国家科技进步二等奖（严重烧伤救治新技术的基础与临床研究，2007，排名第十）
6. 全军教学成果一等奖（医学实验动物学课程的创建与实践，1997，排名第一）