个人简介

柴进，男，博士，副教授，硕士生导师，湖北仙桃人。现为华中农业大学动物科技学院农业动物遗传育种与繁殖教育部重点实验室和“猪种质创新与遗传改良”教育部创新团队”研究人员。主要从事猪的遗传育种研究与教学工作。主要研究兴趣：猪应对应激的响应机制以及应激导致肉质劣变的分子机制，湖北省地方猪种质资源的挖掘与利用研究等。近年来主持国家自然科学青年基金、教育部博士点基金、十二五国家科技支撑计划、湖北省重点实验室开放课题、校自主创新基金等6项，以主要研究人员身份参加973课题、国家自然科学基金、国家支撑计划课题、国家转基因重大专项、公益性行业科研专项等7项，研究结果在《Scientific Reports》、《General and Comparative Endocrinology》、《Meat Science》、《Applied Biochemistry and Biotechnology》、《Molecular Biology Reports》等专业杂志上发表，其中SCI论文21篇，主持申报并获批湖北省地方标准1项，获湖北省科技进步一等奖1项，湖北省科技进步二等奖1项，黄冈市科技进步一等奖1项，申请国家发明专利5件，授权发明专利3件。

教育经历

2001.09 - 2005.06，华中农业大学，动物科学毕业，农学学士
2005.09 - 2010.06，华中农业大学，动物遗传育种与繁殖专业毕业，农学博士

工作经历

2010.07-2013.12，华中农业大学动物科技系讲师
2011.12-2012.11，湖北省首批博士服务团成员、罗田县畜牧局副局长（挂）
2013.12-至今华中农业大学动物科技系副教授

研究领域

猪肌肉生长与发育的分子机制、应激影响猪肉质的分子机制、湖北省地方猪清平猪的保种与利用等

科研成果

1.Chai, J.*, Xiong, Q., Wang, D., Wan, X., Niu, H., Xiang, H., Li, H., Wang, H., Peng, J., Jiang, S., 2017. Identification of novel regulatory GRE-binding elements in the porcine IP3R1 gene promoter and their transcriptional activation under glucocorticoid stimulation. General & Comparative Endocrinology 249, 71-81.
2.Wang, D., Wan, X., Peng, J., Xiong, Q., Niu, H., Li, H., Chai, J.*, Jiang, S.*, 2017. The effects of reduced dietary protein level on aminoacid transporters and mTOR signaling pathway in pigs. Biochemical andBiophysical Research Communication, 485(2):319-327.
3.Wan, X., Wang, D., Xiong, Q., Xiang, H., Li, H., Wang, H., Liu, Z., Niu, H., Peng, J., Jiang, S., Chai, J.*, 2016. Elucidating a molecular mechanism that the deterioration of porcine meat quality responds to increased cortisol based on transcriptome sequencing. Scientific Reports, 6:36589.
4.Xiong, Q., Chai, J. (Co first author),Tao, Y., 2016. Identification and pharmacological analyses of eight naturally occurring caprine melanocortin-1 receptor mutations in three different goat breeds. General and Comparative Endocrinology, 235:1-10.
5.Chai, J., Liu, L., Xiong, Q., Chen, C,. Peng, Y., Jin, W., Zheng, R., Peng, J., Jiang, S., 2013. Molecular cloning, Tissue expression and Analysis with genome DNA methylation of porcine LSD1 gene. Applied Biochemistry and Biotechnology, 169:134-144.
6.Chai, J., Xiong, Q., Zhang, P., Zheng, R., Peng, J., Jiang, S., 2010. Evidence for a new allele at the SERCA1 locus affecting pork meat quality in part through the imbalance of Ca2+ homeostasis. Molecular Biology Reports, 37:613-619.
7.Chai, J., Xiong, Q., Zhang, P., Zheng, R., Peng, J., Jiang, S., 2010. Induction of Ca2+ signal mediated apoptosis and alteration of IP3R1 and SERCA1 expression levels by stress hormone in differentiating C2C12 myoblasts. General and Comparative Endocrinology, 166:241-249.
8.Chai, J., Xiong, Q., Zhang, C., Miao, W., Li, F., Zheng, R., Peng, J., Jiang, S., 2010. Effect of pre-slaughter transport plant on blood constituents and meat quality in halothane genotype of NN Large White×Landrace pigs. Livestock Science, 127:211-217.
9.Xiong, Q., Chai, J. (Co first author), Zhang, P., Wu, J., Jiang, S., Zheng, R., Deng, C., 2011. MyoD control of SKIP expression during pig skeletal muscle development. Molecular Biology Reports, 38:276-274.
10.Xiong, Q., Chai, J. (Co first author), Deng, C., Jiang, S., Liu, Y., Huang, T., Suo, X., Zhang, N., Li, X., Yang, Q., Chen, M., Zheng, R., 2012. Characterization of porcine SKIP gene in skeletal muscle development: Polymorphisms, association analysis, expression and regulation of cell growth in C2C12 cells. Meat Science. 90:490-497.
11.Xiong, Q., Chai, J. (Co first author), Deng, C., Jiang, S., Li, X., Suo, X., Zhang, N., Yang, Q., Liu, Y., Zheng, R., Chen, M., 2012. Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene. Molecular Cell Biochemistry. 360(1-2):225-233.
12.Geng, J., Li, H., Huang, C., Chai, J., Zheng, R., Li, F., Jiang, S., 2017. Functional analysis of HSPA1A and HSPA8 in parturition. Biochem. Biophys. Res. Commun. 483, 371-379.
13.Li, H., Zhou, J., Wei, X., Chen, R., Geng, J., Zheng, R., Chai, J., Li, F., Jiang, S., 2016. miR-144 and targets, c-fos and cyclooxygenase-2 (COX2), modulate synthesis of PGE2 in the amnion during pregnancy and labor. Scientific Reports 6, 27914.
14.Wei, X., Cheng, X., Peng, Y., Zheng, R., Chai, J., Jiang, S., 2016. STAT5a promotes the transcription of mature mmu-miR-135a in 3T3-L1 cells by binding to both miR-135a-1 and miR-135a-2 promoter elements. Int. J. Biochem. Cell Biol. 77, 109.
15.Xiong, Q., Chai, J., Li, X., Suo, X., Zhang, N., Tao, H., Liu, Y., Yang, Q., Jiang, S., Chen, M., 2016. Two tagSNPs in the prolactin receptor gene are associated with growth and litter traits in Boer and Macheng Black crossbred goats. Livest. Sci. 193, 71-77.
16.Li, H., Wu, B., Geng, J., Zhou, J., Zheng, R., Chai, J., Li, F., Peng, J., Jiang, S., 2015. Integrated analysis of miRNA/mRNA network in placenta identifies key factors associated with labor onset of Large White and Qingping sows. Scientific Reports 5, 13074.
17.Ma, J., Chai, J., Shang. Y., Li, Y., Chen, R., Jia, J., Jiang, S., Peng, J., 2015. Swine PPAR-γ2 expression up-regulated in skeletal muscle of transgenic mouse via swine Myozenin1 gene promoter. Transgenic Research, 24(3):409-20.
18.Xiong, Q., Chai, J., Xiong, H., Li, W., Huang, T., Liu, Y., Suo, X., Zhang, N., Li, X., Jiang, S., 2013. Association analysis of HSP70A1A haplotypes with heat tolerance in Chinese Holstein cattle. Cell Stress and Chaperones, 18(6):711-718.
19.Peng, Y., Xiang, H., Chen, C., Zheng, R., Chai, J., Peng, J., Jiang, S., 2013. MiR-224 impairs adipocyte early differentiation and regulates fatty acid metabolism. The international journal of biochemistry & cell biology 45, 1585-1593.
20.Chen, C., Deng, B., Qiao, M., Zheng, R., Chai, J., Ding, Y., Peng, J., Jiang, S., 2012. Solexa sequencing identification of conserved and novel microRNAs in backfat of Large White and Chinese Meishan pigs. PLoS One: 7(2):e31426.
21.Xiong, Q., Deng, C.Y., Chai, J., Jiang, S.W., Xiong, Y.Z., Li, F.E., Zheng, R., 2009. Knockdown of endogenous SKIP gene enhanced insulin-induced glycogen synthesis signaling in differentiating C2C12 myoblasts. Bmb Reports 42, 119.
22.柴进、彭健、熊琪、张昌新、缪文、李凤娥、郑嵘、蒋思文，宰前休息方式对猪福利、血液成分及肉质的影响. 畜牧兽医学报，2009，40（11）: 1645-1650.
23.柴进、彭健、熊琪、张昌新、缪文、李凤娥、郑嵘、蒋思文，宰杀方式对猪血液成分以及肉质的影响. 华中农业大学学报，2009，28（5）: 583-586.
24.柴进、蒋思文，宰前应激对猪肉品质的影响及调控技术研究进展. 养猪，2007，4（8）:27-29.
25.猪骨骼肌特异性表达基因MyoG启动子的克隆及应用. 申请号：201410263464.1. 蒋思文, 李倩倩, 彭健, 柴进, 李凤娥
26.猪骨骼肌特异性表达基因myoz1启动子的克隆及应用. 申请号：20131024909.2. 蒋思文, 尚杨杨, 柴进, 张凤, 李倩倩, 马娟娟
27.猪骨骼肌特异性表达基因tnnc2启动子的克隆及应用. 申请号：201310210445. 蒋思文, 尚杨杨, 柴进, 张凤, 李倩倩, 马娟娟
28.COX1基因作为猪妊娠期长短性状的遗传标记. 授权号：201410052408.3. 柴进, 蒋思文, 彭健, 刘高雯, 郑嵘, 彭永东, 王丹
29.湖北省地方标准《肉猪公路运输技术规程》（DB42/T 878-2013)柴进、蒋思文、彭健、郑嵘、李凤娥

科研项目

1. 畜禽福利饲养关键技术研发2017.07
2. 丹系猪选育2017.01
3. 《松滋市绿色生态畜牧业发展规划》技术咨询合同2016.11
4. 猪经济性状的功能基因组学研究2014.01
5. GRα介导钙离子信号调节猪骨骼肌细胞应激凋亡的研究2014.01
6. 清平猪妊娠期短的优异基因挖掘与分子鉴定2013.01
7. 糖皮质激素受体α（GRα）对猪钙通道基因转录调控的机理研究2013.01
8. 猪经济性状的功能基因组学研究2013.01
9. 钙离子信号通路参与猪肌细胞应激凋亡的机制探讨2011.05

主要奖励

1. 2017年湖北省科技进步一等奖
2. 2014年黄冈市科技进步一等奖
3. 2012年湖北省科技进步二等奖