• 王荡

• 系所

  预防兽医学系

• 职称

  副教授

• 办公房间

  农业微生物学国家重点实验室A座103室

• email

  wangdang@mail.hzau.edu.cn

• 讲授课程

  《动物病毒学》、《动物病毒学实验》、《分子生物学实验技术》等

个人简介

王荡，男，博士，副教授，湖北省杰出青年基金获得者（2017），武汉市晨光计划入选者，中国畜牧兽医学会高级会员，中国细胞生物学会会员。主持国家自然科学基金面上及青年项目、国家重点研发计划子课题项目、湖北省杰出青年基金、中国博士后科学基金面上及特别资助项目、华中农业大学自主科技创新基金优秀人才培育项目等课题，作为骨干参与国家973科技计划项目、国家自然科学基金重大项目等课题。主要运用病毒学、分子生物学、结构生物学和生物信息学等技术方法，开展猪繁殖与呼吸综合征病毒、猪流行性腹泻病毒、猪Delta冠状病毒、口蹄疫病毒等动物病毒与宿主天然免疫信号通路相互作用的研究以及新型疫苗研制。近年来以第一作者或通讯作者在国内外期刊上发表论文20余篇，其中以第一作者在病毒学领域权威杂志《Journal of Virology》发表论文4篇，文章引用900余次，H指数18（SCIE-Web of Science数据库检索），申报国家发明专利3项（其中2项已授权），参编著作1部。

教育经历

2002.09 - 2006.06， 华中农业大学，生物科学（国家生物学基地班），理学学士；
2006.09 - 2011.06， 华中农业大学，预防兽医学，农学博士。

工作经历

2011.07-2013.06，华中农业大学生物学博士后流动站，博士后；
2013.07-2015.12，华中农业大学动物医学院预防兽医学系，讲师；
2016.01-至今，华中农业大学动物医学院预防兽医学系，副教授，硕士研究生导师。

研究领域

动物病毒分子生物学

科研成果

1.Wang D, Fang L, Shi Y, Zhang H, Gao L, Peng G, et al. Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO. Journal of Virology. 2016; 90(4):2090-101.
2.Wang D, Fang L, Wei D, Zhang H, Luo R, Chen H, et al. Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon. Journal of Virology. 2014; 88(17):10252-8.
3.Wang D, Fang L, Li K, Zhong H, Fan J, Ouyang C, et al. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling. Journal of Virology. 2012; 86(17):9311-22.
4.Wang D, Fang L, Li P, Sun L, Fan J, Zhang Q, et al. The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase. Journal of Virology. 2011; 85(8):3758-66.
5.Zhou J, Wang D*, Xi Y, Zhu X, Yang Y, Lv M, Luo C, Chen J, Ye X, Fang L, Xiao S. Assessing activity of Hepatitis A virus 3C protease using a cyclized luciferase-based biosensor. Biochemical and Biophysical Research Communications. 2017; 488(4):621-627.
6.Zhu X, Fang L, Wang D*, Yang Y, Chen J, Ye X, Foda MF, Xiao S*. Porcine deltacoronavirus nsp5 inhibits interferon-beta production through the cleavage of NEMO. Virology. 2017; 502:33-8.
7.Wang D, Fang L, Xiao S Porcine epidemic diarrhea in China. Virus Research. 2016; 226:7-13.
8.Shi Y, Wang D*, Zhu X, Wu Q, Chen H, Xiao S, Fang L*. Molecular cloning and functional characterization of porcine E74-like factor 4 (ELF4). Developmental and Comparative Immunology. 2016; 65:149-58.
9.Zhang H, Ouyang H, Wang D*, Shi J, Ouyang C, Chen H, Fang L*, et al. Mycobacterium tuberculosis Rv2185c contributes to nuclear factor-kappaB activation. Molecular Immunology. 2015; 66(2):147-53.
10.Wang D#, Fan J#, Fang L, Luo R, Ouyang H, Ouyang C, et al. The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus inhibits NF-kappaB signaling by means of its deubiquitinating activity. Molecular Immunology. 2015; 68(2PtA):357-66.
11.Duan E#, Wang D#, Fang L, Ma J, Luo J, Chen H, et al. Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin. Antiviral Research. 2015; 120:122-5.
12.Shi J, Zhang H, Fang L, Xi Y, Zhou Y, Luo R, et al Wang D*. A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications. 2014; 452(4):1046-53.
13.Zhong H#, Wang D#, Fang L, Zhang H, Luo R, Shang M, et al. Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. PloS One. 2013; 8(11):e80976.
14.Wang D#, Cao L#, Xu Z#, Fang L, Zhong Y, Chen Q, et al. MiR-125b reduces porcine reproductive and respiratory syndrome virus replication by negatively regulating the NF-kappaB pathway. PloS One. 2013; 8(2):e55838.
15.Zeng S#, Wang D#, Fang L, Ma J, Song T, Zhang R, et al. Complete coding sequences and phylogenetic analysis of porcine bocavirus. Journal of General Virology. 2011; 92(Pt 4):784-8
16.Wang D, Fang L, Zhao F, Luo R, Chen H, Xiao S. Molecular cloning, expression and antiviral activity of porcine interleukin-29 (poIL-29) . Developmental and Comparative Immunology. 2011; 35(3):378-84.
17.Wang D, Fang L, Liu L, Zhong H, Chen Q, Luo R, et al. Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-lambda1 pathway. Molecular Immunology. 2011; 49(1-2):407-12.
18.Wang D, Fang L, Li P, Chen Q, Luo R, Chen H, et al. Molecular cloning of the porcine RANTES promoter: functional characterization of dsDNA/dsRNA response elements in PK-15 cells. Developmental and Comparative Immunology. 2011; 35(3):345-51.
19.Wang D, Fang L, Bi J, Chen Q, Cao L, Luo R, et al. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells. Virus Genes. 2011; 42(3):388-93.
20.Wang D, Fang L, Luo R, Ye R, Fang Y, Xie L, et al. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels. Biochemical and Biophysical Research Communications. 2010; 399(1):72-8.
21.Wang D, Fang L, Li T, Luo R, Xie L, Jiang Y, Chen H, Xiao S. Molecular cloning and functional characterization of porcine IFN-beta promoter stimulator 1 (IPS-1) . Vet Immunol Immunopathol. 2008;125(3-4):344-53.
22.王　荡, 方六荣, 罗　锐, 谢立兰, 江云波, 陈焕春, 肖少波. 猪IFN-β启动子及其NF-κB结合位点萤光素酶报告载体的构建与活性检测. 中国兽医学报. 2010, 30 (1):107-109.
23.王　荡, 方六荣, 梅小伟, 谢立兰, 陈焕春, 肖少波. 猪维甲酸诱导基因I 的克隆及其在诱导I 型干扰素中的作用. 畜牧兽医学报. 2010, 41 (2):135-140.

科研项目

1. 猪流行性腹泻病毒3C样蛋白酶切割干扰素信号通路关键蛋白的分子机制 2017.09
2. 抗PRRS病毒广谱中和抗体的筛选及其生物学特性研究 2017.07
3. 动脉炎病毒PRRSV和EAV编码的3C样蛋白酶切割NEMO的分子机制 2017.01
4. 抗PRRSV增殖的宿主限制因子的筛选与鉴定 2016.01

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