L

当前位置: 首 页  >  师资队伍  >  教师名录
  • 刘国权
  • 系所

    基础兽医学系
  • 职称

    教授
  • 办公房间

    第一综合楼B座
  • 电子邮件

    liuguoquan@mail.hzau.edu.cn
  • 讲授课程

    《基础生物化学B》、《动物生物化学专题》、等

个人简介

刘国权博士,教授,楚天学者。1987年毕业于南开大学生物系,1990年在中国科学院动物研究所生殖生物学研究所获得硕士学位,1997年在美国俄亥俄医学院获得药理学博士。然后在美国芝加哥西北大学医学院儿科系和儿童医院从事博士后研究,研究内容为LH受体在睾丸间质细胞腺瘤中的信号传导。2003年就任美国芝加哥伊利诺利大学医学院药理系研究助理教授,从事研究血管生成和内皮细胞炎症反应相关的信号传导。2012年10月加入华中农业大学动物医学院基础兽医系动物生理生化教研室。曾在《New England Journal of Medicine》、《Blood》、《ATVB》等期刊发表文章。目前研究兴趣:(1)在炎症反应和组织损伤中内皮细胞介导的白细胞募集和浸润。(2)巨噬细胞极化的信号传导及在炎症反应中的作用。

教育经历

1991-1996 药理博士学位, 俄亥俄医学院药理系, 托莱多, 俄亥俄, 美国(Medical College of Ohio, Toledo, O;H)
1987-1990 生理硕士学位, 中国科学院动物研究所, 北京
1983-1987 生物学士学位, 南开大学生物系, 天津

工作经历

2012-目前 特聘教授,楚天学者,博导. 华中农业大学基础兽医系生物化学教授

研究领域

炎症反应中天然免疫细胞的信号转导。

科研成果

A著作类


B论文类
Yan M, Zhang X, Chen A, Gu W, Liu J, Ren X, Wu X, Place AT, Minshall RD, Liu G. Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1–VE-cadherin interaction. FASEB J. 2017 Jul 12. pii: fj.201700280R. doi: 10.1096/fj.201700280R. [Epub ahead of print].
Ren X, Fu X, Zhang X, Chen S, Huang S, Yao L, Liu G Testosterone regulates 3T3-L1 pre-adipocyte differentiation and epididymal fat accumulation in mice through modulating macrophage polarization. Biochem Pharmacol. 2017 140:73-88.
Yan M, Hou M, Liu J, Zhang S, Liu B, Wu X, Liu G. Regulation of iNOS-derived ROS generation by HSP90 and Cav-1 in porcine reproductive and respiratory syndrome virus-infected swine lung injury. Inflammation 2017; 40(4):1236-1244.
Gu W, Zhan H, Zhou XY, Yao L, Yan M, Chen A, Liu J, Ren X, Zhang X, Liu JX, Liu G. MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin. FEBS Lett. 2017; 591(3):513-526.
Liu J, Hou M, Yan M, Lü X, Gu W, Zhang S, Gao J, Liu B, Wu X, Liu G. ICAM-1-dependent and ICAM-1-independent neutrophil lung infiltration by porcine reproductive and respiratory syndrome virus infection. Am J Physiol Lung Cell Mol Physiol. 2015; 309(3):L226-36.
Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD. G protein-dependent basal and evoked endothelial cell vWF secretion. Blood. 2014; 123(3):442-50. 
Gao J, Zhao L, Shahzad M, Zhang D, Liu G, Hou B, Li J. Expression of endothelin-1 and its receptors in the lungs of broiler chickens exposed to high-altitude hypoxia. Avian pathology, 2013, 42(5) :416-9
Piegeler T, Votta-Velis EG, Liu G, Place AT, Schwartz DE, Beck-Schimmer B, Minshall RD, Borgeat A. Antimetastatic Potential of Amide-linked Local Anesthetics: Inhibition of Lung Adenocarcinoma Cell Migration and Inflammatory Src Signaling Independent of Sodium Channel Blockade. Anesthesiology. 2012; 117(3):548-59.
Liu G, Place AT, Chen Z, Brovkovych VM, Vogel SM, Muller WA, Skidgel RA, Malik AB, and Minshall RD. ICAM-1-activated Src and eNOS Signaling Increase Endothelial Cell Surface PECAM-1 Adhesivity and Neutrophil Transmigration. Blood. 2012; 42(5):416-9.
Place AT, Chen Z, Bakhshi FR, Liu G, O’Bryan JP, Minshall RD. Cooperative role of caveolin-1 and Cbp in Csk-mediated negative regulation of c-Src. Molecular Pharmacology 2011; 80 (4):665-72.
Liu G, Vogel SM, Gao X, Javaid K, Hu G, Danilov SM, Malik AB, Minshall RD. Src phosphorylation of endothelial cell surface ICAM-1 mediates neutrophil adhesion and contributes to the mechanism of lung inflammation. Arterioscler. Thromb. Vasc. Biol. 2011; 31:1342-50.
Han J, Liu G, Profirovic J, Niu J, Voyno-Yasenetskaya TA. Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor. FASEB J. 2009; 3:4193-4206.
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA. G13 regulates MEF2-dependet gene transcription in encothelial cells: roles in angiogenesis. Angiogenesis. 2009; 12(1):1-15.
Pals-Rylaarsdam R, Liu G, Brickman W, Duranteau L, Monroe J, El-Awady MK,Gad YZ, Shenker A. A novel double mutation of the luteinizing hormone receptor in a kindred with familial Leydig cell hypoplasia and male pseudohermaphroditism. Endocr Res. 2005; 31:307-23.
Liu G, and Voyno-Yasenetskaya TA. Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: Crosstalk with Gα13 signaling. J Biol Chem. 2005; 280: 39042-9.
Kvachnina E, Liu G, Dityatev A, Renner U, Dumuis A, Richter DW, Dityateva G, Schachner, Voyno-Yasenetskaya TA, and Ponimaskin EG. 5-Hydroxytryptamine (7) receptor is coupled to Gα subunits of heterotrimeric G12 protein to regulate gene transcription and neuronal morphology. J Neuroscience 2005; 25: 7821-30. (co-first author).
Liu G and Shenker A. The role of activating LH receptor gene mutations in Leydig cell hyperplasia and neoplasia. The Journal of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University 2002; 8: 34-46.
Bebia Z, Somers JP, Liu G, Llhrig L, Shenker A, Zeleznik AJ. Adenovirus-directed expression of LH receptors in immature granulosa cells indicates differential effects of FSH and LH on steroid production. Endocrinology 2001; 142: 2252-9.
Liu G, Duranteau L, Monroe J, Doyle DA, Carel J-C, Shenker A. Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N. Engl. J. Med. 1999; 341:1731-1735.
Liu G, Xie ZJ, Modyanov NN, Askari A. Restoration of phosphorylation capacity to the dormant half of the alpha subunits of Na+/K+-ATPase. FEBS Lett 1996; 390:323-326.
Xie ZJ, Wang Y, Liu G, Zolotarjova N, Periyasamy SM, Askari A.Similarities and differences between the properties of native and recombinant Na+/K+-ATPases. Arch Biochem Biophys 1996; 330:153-162.
Xie ZJ, Li H, Liu G, Wang Y, Askari A, Mercer RW. Cloning of the dog Na,K-ATPase alpha1 subunit. In: Bamberg E, Schoner W, eds, The Sodium Pump: Structure Mechanism, Hormonal Control and Its Role in Disease.Darmstadt, Steinkoff;  New York, Springer, 1994; pp.49-52.
DeTomaso AW, Xie ZJ, Liu G, Mercer RW. Expression, targeting, and assembly of functional Na,K-ATPase polypeptides in baculovirus-infected insect cells. J Biol Chem 1993; 268:1470-1478.
Liu G, Chen D. Investigation on the role of cytoskeleton in the resumption and rotation of oocyte meiosis apparatus. Acta Zool Sin 1993; 39(1):96-102.
Chen D, Song X, Zhao X, Duan C, Liu G, Song Y. Mechanism of fertilization of amphioxus: The ultrastructure of the fertilized eggs. Acta Zool Sin 1991; 37(4):422-426.

科研项目

1. 佐剂安全性协作评估协议 2017.05
2. 免疫缺陷小鼠肾包膜下移植猪肺模型的构建以及猪呼吸系统疾病研发平台的创立 2015.01
3. 猪肺部感染组织中中性粒细胞的募集、浸润及SHP-2介导ICAM-1信号调控机制 2014.01
4. ICAM-1和SHP-2蛋白互作与中性粒细胞在PRRSV感染猪肺组织中的募集和侵润 2013.01

主要奖励

版权所有:Copyright © 华中农业大学 动物科学技术学院动物医学院

地址:湖北省武汉市洪山区狮子山1号华中农业大学动科楼

邮箱:myoffice@mail.hzau.edu.cn

电话:027-87282091

邮政编码:430070

微信公众号