个人简介

2007年获华中农业大学动物遗传育种与繁殖专业博士学位；2013-2014年在英国诺丁汉大学访问交流，访问期间从事猪诱导干细胞（iPS）研究工作。教学方面，目前承担本科生《普通遗传学》和《动物分子生物学》等课程的教学工作。研究领域为动物分子遗传与细胞生物学，研究方向为猪肌肉生长及饲料转化效率遗传调控分子机理。主要研究策略是运用生物信息学方法分析全基因组测序或芯片数据，鉴定关键候选基因，然后通过反向遗传学手段进行验证。目前已在《Cell Death & Disease》、《Journal of Cell Science》、《Frontiers in Immunology》、《Animal Genetics》等杂志上发表研究论文30余篇。已申请和授权国家发明专利10项。主持国家自然科学基金三项、教育部新教师基金一项、动物转基因子项目及863子项目各一项；作为骨干参与国家转基因重大专项、国家自然基金重点、863计划、973计划等项目。研究生招生方向：动物遗传育种与繁殖（090501）专业的02方向。

教育经历

1996.09 - 2000.06，华中农业大学，畜牧学学士
2002.09 - 2007.06，华中农业大学，动物遗传育种与繁殖专业博士

工作经历

2016.1-至今，华中农业大学，教授
2010.1-2015.12，华中农业大学，副教授
2007.7-2009.12，华中农业大学，讲师
2013.10-2014.06，英国诺丁汉大学，访问学者

研究领域

1. QTL主效基因及致因突变鉴定：应用基因芯片、测序等方法在商业群体或F2分离群体中鉴定生长、饲料效率、胴体等性状的主效基因、分子标记及致因突变；
2. 猪基因组学：包括猪3D基因组，猪基因组ENCODE，功能突变鉴定等；
3. 猪育种研究：包括分子标记辅助选择和全基因组选择。

科研成果

论文类
1. Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL/6J × Kunming F2 Mice Population Using Genome-Wide Association Study. Yuanxin Miao, Fathia Soudy, Zhong Xu, Mingxing Liao, Shuhong Zhao and Xinyun Li (通讯作者). BioMed Research International. 2017, https://doi.org/10.1155/2017/7132941
2. Liangliang Fu, Yueyuan Xu, Ye Hou, Xiaolong Qi, Lian Zhou, Huiying Liu, Yu Luan, Lu Jing, Yuanxin Miao, Shuhong Zhao, Huazhen Liu and Xinyun Li (共同通讯). Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs. Scientific Reports, 2017, 7 :45291.
3. Congcong Li, Huabin He, An Liu, Huazhen Liu, Haibo Huang,Changzhi Zhao, Lu Jing, Juan Ni, Lilin Yin, Suqin Hu, Hui Wu, Xinyun Li (共同通讯) and Shuhong Zhao. natural Functional snPs in miR-155 alter its expression level, Blood cell counts, and immune responses. Front. Immunol. 2016 , 7 :295.
4. Yunxia Zhao, Ye Hou, Fei Liu, An Liu, Lu Jing, Changzhi Zhao, Yu Luan, Yuanxin Miao, Shuhong Zhao, and Xinyun Li (通讯作者). Transcriptome Analysis Reveals that Vitamin A Metabolism in the Liver Affects Feed Efficiency in Pigs. G3, 2016,6, 3615-24.
5. Wei Wei, Weiya Zhang, Jianbo Bai, Haixin Zhang, Yuanyuan Zhao, Xinyun Li (通讯作者) and Shuhong Zhao. The NF-κB-modulated microRNAs miR-195 and miR-497 inhibit myoblast proliferation by targeting igf1r insr and cyclin genes. Journal of cell science, 2016, 129, 39-50.
6. Yuanxin Miao, Jinzeng Yang, Zhong Xu, Lu Jing, Shuhong Zhao and Xinyun Li (通讯作者) RNA Sequencing Identifies Upregulated Kyphoscoliosis Peptidase and Phosphatidic Acid Signaling Pathways in Muscle Hypertrophy Generated by Transgenic Expression of Myostatin Propeptide. Int. J. Mol. Sci. 2015, 16, 7976-7994.
7. Weiya Zhang, Wei Wei, Yuanyuan Zhao, Shuhong Zhao, Xinyun Li (通讯作者). The microRNA, miR-29c, participates in muscle development through targeting the YY1 gene and is associated with postmortem muscle pH in pigs. Front. Agr. Sci. Eng. 2015, 2(4): 311–317.
8. Xinyun Li (第一作者), Juan Tang, Jing Xu, Mengjin Zhu, Jianhua Cao, Ying Liu, Mei Yu and Shuhong Zhao. *The Inflammation-Related Gene S100A12 Is Positively Regulated by C/EBPβ and AP-1 in Pigs. Int. J. Mol. Sci. 2014, 15, 13802-13816.
9. Wei Wei, He Huabin, Zhang Weiya, Zhang Haixin, Bai Jianbo, Liu Huazhen, Cao Jianhua, Chang Kinchow, Xinyun Li (通讯作者), Shuhong Zhao. Mir-29 targets AKT3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development, Cell Death & Disease, 2013, 4(e668), pp 1-10.
10. He Shen, Teng Liu, Liangliang Fu, Shuhong ZhaoS, Bin Fan, Jianhua Cao, Xinyun Li (通讯作者). Identification of microRNAs involved in dexamethasone-induced muscle atrophy. Mol Cell Biochem. 2013, 381(1-2):105-13.
11. Congcong Li, Huabin He, Mengjin Zhu, Shuhong Zhao, Xinyun Li (共同通讯). Molecular characterization of the porcine miR-155 and its regulation roles in the TLR3/TLR4 pathways. Developmental & Comparative Immunology, 2013, 39 (1-2) :110-116.
12. Shengsong Xie, Xinyun Li (共同一作), Teng Liu, Jianhua Cao, Qiang Zhong, Shuhong Zhao. Discovery of Porcine microRNAs in Multiple Tissues by a Solexa Deep Sequencing Approach. 2011, PLoS ONE, 6(1): e16235.
13. Huabin He, Shuhong Zhao and Xinyun Li (通讯作者). Chromosome mapping of five differently expressed miRNAs in porcine skeletal muscle development. Arch Tierz, 2010, 53: 734-736.
14. Xinyun Li (共同一作), Chunmei Han, Yun Wang, Huazhen Liu, Zhenfang Wu, Qinghua Gao and Shuhong Zhao. Expression patterns and association analysis of the porcine DHX58 gene. Animal genetics, 2010; 41 (5): 537-40.
15. Xinyun Li (第一作者), Huazhen Liu, Shulin Yang, Zhonglin Tang, Yuehui Ma, Mingxing Chu, Kui Li. Characterization analysis and polymorphism detection of porcine myd88 gene. Genetics and Molecular Biology, 2009; 32 (2): 295-300.
16. Xinyun Li (第一作者), Zhengmao Zhu, Delin Mo, Heng Wang, Shulin Yang, Shuhong Zhao and Kui Li. Comparative molecular characterization of ADSS1 and ADSS2 genes in pig (Sus scrofa). Comparative Biochemistry and Physiology, 2007; 147(2):271-277.
17. Xinyun Li (第一作者), Bang Liu, Bin Fan, Mei Yu, Mengjing Zhu, Tongan Xiong and Kui Li .Mapping, tissue distribution and polymorphism study of the porcine SOCS2 and SOCS3 genes. Asian-Australasian Journal of Animal Sciences, 2006; 19(2):165-170.

科研项目

主持国家自然科学基金三项、教育部新教师基金一项、动物转基因子项目及863子项目各一项

主要奖励

无