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  • 何启盖
  • 系所

    预防兽医学系
  • 职称

    三级教授
  • 办公房间

    农业微生物学国家重点实验室A座110室
  • 电子邮件

    he628@mail.hzau.edu.cn
  • 讲授课程

    《兽医学》(本科生)、《兽医诊断原理与技术进展》和《猪病学进展》(硕士)

个人简介

何启盖,男,博士,教授,博士生导师。2002.11-2006.3:在新加坡国立大学做访问学者和博士后研究。入选教育部新世纪优秀人才, 是国家生猪产业技术体系疾病控制岗位科学家,农业部规模化养殖场疫病净化评估认证专家,国家生猪产业技术创新战略联盟副理事长,亚洲猪病学会国家理事。主要开展猪伪狂犬病、猪圆环病毒病、猪流行性腹泻、副猪嗜血杆菌病、传染性胸膜肺炎等疾病的病原分离、致病机理、新型疫苗、诊断制剂与综合防控措施研究。“12.5”和“13.5”期间,承担了国家自然科学基金、国家重点研发计划、国家生猪产业技术体系项目、农业部公益性行业科技专项等课题。在EID、Journal of Virology、Virology、畜牧兽医学报等国内外重要学术刊物发表70多篇研究文章,获得3项新兽药注册证书和8项发明专利。获3项国家级、省部级奖励。常年服务国内外养猪企业的疾病防控与净化。已培养毕业近80名国内外研究生,注重培养学生学以致用,解决临床实际问题。

教育经历

1984.09 - 1989.06, 西南民族大学,兽医专业毕业,医学学士
1990.09 - 1993.06, 四川农业大学,传染病学与预防兽医学专业毕业,农学硕士
1996.09-2000.06,华中农业大学,动物遗传育种与繁殖(抗病方向),农学博士

工作经历

1993.06-2002.11,华中农业大学助教、讲师,副教授,硕士生导师。
2002.11-2006.03,新加坡国立大学访问学者和博士后
2006.04-现在,华中农业大学教授,硕士和博士生导师

研究领域

猪传染病临床诊断和控制、致病机制、新型疫苗与诊断制剂。

科研成果

A著作类
1. 主编之一,《伪狂犬病》,中国农业出版社,2015
2. 副主编,《兽医手册》(中国农业出版社)和《中国生猪产业技术进展》(湖南科学技术出版社);副主译《生物安全选集XI》(中国农业出版社)。
3.参编(译),《默克兽医手册》(中国农业出版社)、《人兽共患病学》(四川科学技术出版社)
B论文类
Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae. FEMS Microbiol Lett. 2009 Nov; 300(1):83-9.
Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae.; FEMS Microbiol Lett. 2009 Nov; 300(1):83-9
Wang Yang, Fang Ying, Liu Yingyu, Chen Pin, Li Wentao, Liu Shuqing, Zou Haoyong, He Qigai. Development and evaluation of loop-mediated isothermal amplification for rapid detection of Haemophilus parasuis. FEMS Microbiology Letters, 2010, 313(1):54-60
Huimin Zhang, Wentao Li, Zonghai Sheng, Heyou Han and Qigai He. Ultrasensitive detection of porcine circovirus type 2 using gold (III) enhanced chemiluminescence immunoassay. Analyst, 2010,135(7):1680-1685
Chen H, Cheng L, Yang S, Liu X, Liu Y, Tang J, Li X, He Q, Zhao S. Molecular characterization, induced expression, and transcriptional regulation of porcine S100A12 gene. Mol Immunol. 2010 Apr; 47(7-8):1601-7.
Pin Chen,Yingyu Liu,Chong Liu,Haoyong Zou,Yang Wang,Wentao Li,Dingren Bi and Qigai He. Laboratory Detection of Haemophilus parasuis with Decreased Susceptibility to Nalidixic Acid and Enrofloxacin Due to GyrA and ParC Mutations. Journal of Animal and Veterinary Advances. 2011, 10(21):2870-2873
Hao-Yong Zou, Xin-Jun Liu, Feng-Ying Ma, Pin Chen, Rui Zhou, Qi-Gai He. Attenuated Actinobacillus pleuropneumoniae as a bacterial vector for expression of Mycoplasma hyopneumoniae P36 gene. The Journal of Gene Medicine. 2011, 13(4):221-229
Zhao Z, Wang C, Xue Y, Tang X, Wu B, Cheng X, He Q, Chen H. The occurrence of Bordetella bronchiseptica in pigs with clinical respiratory disease.Vet J. 2011 Jun; 188(3):337-40.
Wang Y, Liu C, Fang Y, Liu X, Li W, Liu S, Liu Y, Liu Y, Charreyre C, Audonnet JC, Chen P, He Q. Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis. BMC Genomics. 2012 Feb 13;13:68
Cheng S, Zhang M, Li W, Wang Y, Liu Y, He Q; Proteomic analysis of porcine alveolar macrophages infected with porcine circovirus type 2; J Proteomics. 2012 Jun 18;75(11):3258-69
Yingyu Liu, Pin Chen, Yang Wang, Wentao Li, Shuang Cheng, Chunmei Wang, Anding Zhang, Qigai He;Transcriptional profiling of Haemophilus parasuis SH0165 response to tilmicosin. Microbial Drug Resist. 2012 Dec;18(6):604-15
Liu C, Wang Y, Zhang H, Cheng S, Charreyre C, Audonnet JC, Chen P, He Q. Porcine coronin 1A contributes to nuclear factor-kappa B (NF-κB) inactivation during Haemophilus parasuis infection. PLoS One. 2014 Aug 5; 9(8):e103904.
Hu H, Wang C, Guo X, Li W, Wang Y, He Q. Broad activity against porcine bacterial pathogens displayed by two insect antimicrobial peptides moricin and cecropin B. Mol Cells. 2013 Feb; 35(2):106-14
Li W, Liu S, Wang Y, Deng F, Yan W, Yang K, Chen H, He Q, Charreyre C, Audoneet JC. Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type 2. BMC Genomics. 2013 May 27; 14:35310.
Cheng S, Yan W, Gu W, He Q. The ubiquitin-proteasome system is required for early stages of porcine circovirus type 2 replication. Virology. 2014 May; 456-457:198-204.
Chen F, Hu H, Li Z, Huang J, Cai X, Wang C, et al. Deletion of HAPS_2096 Increases Sensitivity to Cecropin B in Haemophilus parasuis. J Mol Microbiol Biotechnol 2015;25:284-91.
Chen F, Zhu Y, Wu M, Ku X, Yao L, He Q. Full-Length Genome Characterization of Chinese Porcine Deltacoronavirus Strain CH/SXD1/2015. Genome Announc 2015;3.
Chen F, Zhu Y, Wu M, Ku X, Ye S, Li Z, et al. Comparative Genomic Analysis of Classical and Variant Virulent Parental/Attenuated Strains of Porcine Epidemic Diarrhea Virus. Viruses 2015;7:5525-38.
Guo X, Hu H, Chen F, Li Z, Ye S, Cheng S, et al. iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. J Proteomics 2016;130:65-75.
Li W, Wicht O, van Kuppeveld FJ, He Q, Rottier PJ, Bosch BJ. A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion. J Virol 2015;89:8077-81.
Ye S, Li Z, Chen F, Li W, Guo X, Hu H, et al. Porcine epidemic diarrhea virus ORF3 gene prolongs S-phase, facilitates formation of vesicles and promotes the proliferation of attenuated PEDV. Virus Genes 2015;51:385-92.
Ye S, Shao K, Li Z, Guo N, Zuo Y, Li Q, et al. Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter. ACS Appl Mater Interfaces 2015;7:21571-9.
Li, Z., Chen, F., Ye, S., Guo, X., Muhanmmad Memon, A., Wu, M. & He, Q. (2016). Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain. Viruses 8, 323.
Chen, F., Ku, X., Li, Z. & other authors (2016). Genetic characteristics of porcine epidemic diarrhea virus in Chinese mainland, revealing genetic markers of classical and variant virulent parental/attenuated strains. Gene 588, 95-102.
Deng, F., Ye, G., Liu, Q. & other authors (2016). Identification and comparison of receptor binding characteristics of the spike protein of two porcine epidemic diarrhea virus strains. Viruses 8, 55.
Guo, X., Hu, H., Chen, F., Li, Z., Ye, S., Cheng, S., Zhang, M. & He, Q. (2016). iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. Journal of proteomics 130, 65-75.Li, W., van Kuppeveld, F. J., He, Q., Rottier, P. J. & Bosch, B.-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus research 226, 117-127.
Guo, X., Zhang, M., Zhang, X. & other authors (2017). Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication. Viruses 9, 53.
Li, W., Luo, R., He, Q., van Kuppeveld, F. J., Rottier, P. J. & Bosch, B.-J. (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus research 235, 6-13.
Memon AM, Bhuyan AA, Chen F, Guo X, Menghwar H, Zhu Y, Ku X, Chen S, Li Z, He Q. (2017). Development and Validation of Monoclonal Antibody-Based Antigen Capture ELISA for Detection of Group A Porcine Rotavirus.Viral Immunol. 30(4):264-270.
Lei Z, Liu Q, Yang B, Ahmed S, Xiong J, Song T, Chen P, Cao J, He Q.(2017).Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs.Front Vet Sci. May 1;4:61.
Lei Z, Liu Q, Yang B, Xiong J, Li K, Ahmed S, Hong L, Chen P, He Q, Cao J.(2017). Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs.Front Pharmacol.23;8:294. 

科研项目

国家生猪产业技术体系项目(CARS-36,CARS-35),重点开展猪瘟伪狂犬病净化、猪蓝耳病和常见细菌病的综合防控;
国家重点研发专项-猪重要疫病抗体快速检测技术研究(2016YFD0500702)(重点开展猪流行性腹泻sIgA-ELISA试剂盒研制)
武汉市国际合作课题-猪流行性腹泻新型疫苗和鉴别诊断方法研究和企业合作课题。
企业合作课题多项:涉及新型疫苗和诊断试剂开发;猪场疾病净化与控制。

主要奖励

1. 2012年参与获得国家科技进步一等奖(排名第5),
2. 2016年获得国家科技进步二等奖(排名第3)
3.以第一完成人获得新兽药注册证书2项

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